Dorota Scieglinska1, Agnieszka Gogler-Piglowska2, Dorota Butkiewicz2, Mykola Chekan3, Ewa Malusecka2, Jolanta Harasim4, Anna Habryka2, Zdzislaw Krawczyk2. 1. Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland dorotas@io.gliwice.pl. 2. Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland. 3. Department of Tumor Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland. 4. Department of Thoracic Surgery, The Medical University of Silesia, Zabrze, Poland.
Abstract
BACKGROUND/AIM: It has been shown that HSPA2 protein, a testis-enriched member of HSPA/HSP70 family, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression in tumors and its clinical/prognostic significance are obscure. Herein we aimed to investigate the expression of HSPA2 in various types of tumors and to determine the possible clinical and prognostic significance of HSPA2 in non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS: Tissue microarrays and postoperative NSCLC tumors were tested for HSPA2 by immunohistochemistry. RESULTS: HSPA2 is expressed in the majority of tumor histotypes. In NSCLC patients (n=85), nuclear HSPA2 expression was associated with histology, TNM staging and prognosis. High HSPA2 expression was significantly related to shorter overall survival (OS) in stage I-II patients. In multivariate analysis, high HSPA2, together with stage IIIA and male sex, were associated with shorter OS in the whole group. CONCLUSIONS: As exemplified in NSCLC the status of HSPA2 in human tumors may have certain prognostic significance. Copyright
BACKGROUND/AIM: It has been shown that HSPA2 protein, a testis-enriched member of HSPA/HSP70 family, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression in tumors and its clinical/prognostic significance are obscure. Herein we aimed to investigate the expression of HSPA2 in various types of tumors and to determine the possible clinical and prognostic significance of HSPA2 in non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS: Tissue microarrays and postoperative NSCLC tumors were tested for HSPA2 by immunohistochemistry. RESULTS:HSPA2 is expressed in the majority of tumor histotypes. In NSCLCpatients (n=85), nuclear HSPA2 expression was associated with histology, TNM staging and prognosis. High HSPA2 expression was significantly related to shorter overall survival (OS) in stage I-II patients. In multivariate analysis, high HSPA2, together with stage IIIA and male sex, were associated with shorter OS in the whole group. CONCLUSIONS: As exemplified in NSCLC the status of HSPA2 in humantumors may have certain prognostic significance. Copyright