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Literature DB >> 24920591

In pursuit of an inhibitory drug for the proton channel.

Amaury Pupo¹, Carlos Gonzalez León².

Abstract

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Year: 2014 PMID： 24920591 PMCID： PMC4103314 DOI： 10.1073/pnas.1408808111

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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23 in total

1. Hydrophobic plug functions as a gate in voltage-gated proton channels.

Authors: Adam Chamberlin; Feng Qiu; Santiago Rebolledo; Yibo Wang; Sergei Y Noskov; H Peter Larsson
Journal: Proc Natl Acad Sci U S A Date: 2013-12-30 Impact factor: 11.205

Review 2. Philosophy of voltage-gated proton channels.

Authors: Thomas E DeCoursey; Jonathan Hosler
Journal: J R Soc Interface Date: 2013-12-18 Impact factor: 4.118

3. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

Authors: P Hidalgo; R MacKinnon
Journal: Science Date: 1995-04-14 Impact factor: 47.728

4. Autoimmune disorder phenotypes in Hvcn1-deficient mice.

Authors: Mari Sasaki; Akihiro Tojo; Yoshifumi Okochi; Nana Miyawaki; Daisuke Kamimura; Akihito Yamaguchi; Masaaki Murakami; Yasushi Okamura
Journal: Biochem J Date: 2013-03-01 Impact factor: 3.857

5. Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis.

Authors: Yifan Wang; Shu Jie Li; Juncheng Pan; Yongzhe Che; Jian Yin; Qing Zhao
Journal: Biochem Biophys Res Commun Date: 2011-07-29 Impact factor: 3.575

6. Water wires in atomistic models of the Hv1 proton channel.

Authors: Mona L Wood; Eric V Schow; J Alfredo Freites; Stephen H White; Francesco Tombola; Douglas J Tobias
Journal: Biochim Biophys Acta Date: 2011-08-05

7. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains.

Authors: Liang Hong; Medha M Pathak; Iris H Kim; Dennis Ta; Francesco Tombola
Journal: Neuron Date: 2013-01-23 Impact factor: 17.173

8. Zn(2+) induces apoptosis in human highly metastatic SHG-44 glioma cells, through inhibiting activity of the voltage-gated proton channel Hv1.

Authors: Yifan Wang; Shangrong Zhang; Shu Jie Li
Journal: Biochem Biophys Res Commun Date: 2013-07-24 Impact factor: 3.575

In pursuit of an inhibitory drug for the proton channel.

1. Hydrophobic plug functions as a gate in voltage-gated proton channels.

Review 2. Philosophy of voltage-gated proton channels.

3. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

4. Autoimmune disorder phenotypes in Hvcn1-deficient mice.

5. Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis.

6. Water wires in atomistic models of the Hv1 proton channel.

7. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains.

8. Zn(2+) induces apoptosis in human highly metastatic SHG-44 glioma cells, through inhibiting activity of the voltage-gated proton channel Hv1.

9. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

10. Human voltage-gated proton channel hv1: a new potential biomarker for diagnosis and prognosis of colorectal cancer.

1. The Hv1 proton channel responds to mechanical stimuli.

2. Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation.

3. A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain.

4. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions.