BACKGROUND: The transfer of peanut allergy has been reported following solid organ transplantation. OBJECTIVE: Present a case of peanut sensitization following combined pancreas-and-kidney transplantation. METHODS: Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant. RESULTS: The organ recipient's pre-transplant peanut IgE levels were negative. At 1 month post-transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy. CONCLUSION AND CLINICAL RELEVANCE: We report the development of IgE peanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.
BACKGROUND: The transfer of peanutallergy has been reported following solid organ transplantation. OBJECTIVE: Present a case of peanut sensitization following combined pancreas-and-kidney transplantation. METHODS: Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant. RESULTS: The organ recipient's pre-transplant peanutIgE levels were negative. At 1 month post-transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy. CONCLUSION AND CLINICAL RELEVANCE: We report the development of IgEpeanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.
Authors: Carolyn Word; Erin Klaffky; Christina Ortiz; Thamiris Palacios; Shawn Pelletier; Walter Oliveira; Barbara Greb; Lisa Workman; Thomas Platts-Mills; Julia Wisniewski Journal: J Allergy Clin Immunol Pract Date: 2015-04-22
Authors: Yannick D Muller; Julien Vionnet; Franziska Beyeler; Philippe Eigenmann; Jean-Christoph Caubet; Jean Villard; Thierry Berney; Kathrin Scherer; Francois Spertini; Michael P Fricker; Claudia Lang; Peter Schmid-Grendelmeier; Christian Benden; Pascale Roux Lombard; Vincent Aubert; Franz Immer; Manuel Pascual; Thomas Harr Journal: Am J Transplant Date: 2019-10-19 Impact factor: 8.086