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Literature DB >> 2491781

Close flanking markers for neurofibromatosis type I (NF1).

M Upadhyaya¹, M Sarfarazi, S M Huson, W Broadhead, A Fryer, P S Harper.

Abstract

A genetic linkage study with 16 polymorphic DNA markers spanning the region 17p11-17q24 in 22 NF1 families is presented. Close linkage between NF1 and eight pericentromeric markers (HHH202, EW206, CRI-L946, EW203, EW301, FG2, p17H8, and CRI-L581) has been found, probe HHH202 being the closest marker to NF1. Genetic heterogeneity has been excluded. The study of multiply informative meioses suggests that the probes HHH202 and RW206 are flanking markers for NF1. The most likely order on the basis of multiply informative meioses and multipoint mapping is pter-pA10.41-EW301-cen-HHH202-NF1-EW206-++ +EW207-qter.

Entities: Disease Gene

Mesh：

Substances：
Genetic Markers

Year: 1989 PMID： 2491781 PMCID： PMC1715482

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

8 in total

1. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors: L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal: Proc Natl Acad Sci U S A Date: 1977-03 Impact factor: 11.205

2. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

Review 3. Linkage of NF1 to 12 chromosome 17 markers: a summary of eight concurrent reports.

Authors: M H Skolnick; B Ponder; B Seizinger
Journal: Genomics Date: 1987-12 Impact factor: 5.736

4. Chromosome 17 markers and von Recklinghausen neurofibromatosis: a genetic linkage study in a British population.

Authors: M Upadhyaya; M Sarfarazi; S M Huson; K Stephens; W Broadhead; P S Harper
Journal: Genomics Date: 1987-12 Impact factor: 5.736

5. Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene.

Authors: B R Seizinger; G A Rouleau; L J Ozelius; A H Lane; A G Faryniarz; M V Chao; S Huson; B R Korf; D M Parry; M A Pericak-Vance
Journal: Cell Date: 1987-06-05 Impact factor: 41.582

6. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

7. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17.

Authors: D Barker; E Wright; K Nguyen; L Cannon; P Fain; D Goldgar; D T Bishop; J Carey; B Baty; J Kivlin
Journal: Science Date: 1987-05-29 Impact factor: 47.728

8. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

8 in total

6 in total

1. The von Recklinghausen neurofibromatosis region on chromosome 17--genetic and physical maps come into focus.

Authors: F S Collins; B A Ponder; B R Seizinger; C J Epstein
Journal: Am J Hum Genet Date: 1989-01 Impact factor: 11.025

2. A cytogenetic deletion, del(17)(q11.22q21.1), in a patient with sporadic neurofibromatosis type 1 (NF1) associated with dysmorphism and developmental delay.

Authors: M Upadhyaya; S H Roberts; J Maynard; E Sorour; P W Thompson; M Vaughan; A O Wilkie; H E Hughes
Journal: J Med Genet Date: 1996-02 Impact factor: 6.318

3. A genetic study of neurofibromatosis 1 in south-western Ontario. I. Population, familial segregation of phenotype, and molecular linkage.

Authors: D I Rodenhiser; M B Coulter-Mackie; J H Jung; S M Singh
Journal: J Med Genet Date: 1991-11 Impact factor: 6.318