Literature DB >> 24914331

miRNA polymorphisms and risk of gastric cancer in Asian population.

Hai-Bing Hua1, Ting-Ting Yan1, Qing-Min Sun1.   

Abstract

miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.

Entities:  

Keywords:  Gastric cancer; Polymorphism; Risk; miRNA

Mesh：

Substances：

Year:  2014        PMID： 24914331      PMCID： PMC4024780          DOI： 10.3748/wjg.v20.i19.5700

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  55 in total

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