Literature DB >> 24913157

Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Ines Moura1, Marc Monot2, Chiara Tani3, Patrizia Spigaglia4, Fabrizio Barbanti1, Nathalie Norais3, Bruno Dupuy2, Emilio Bouza5, Paola Mastrantonio1.   

Abstract

Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24913157      PMCID： PMC4135993          DOI： 10.1128/AAC.02350-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Lack of association of outcomes with treatment duration and microbiologic susceptibility data in Clostridium difficile infections in a non-NAP1/BI/027 setting.

Authors:  Anilrudh A Venugopal; Kathleen Riederer; Shilpa M Patel; Susanna Szpunar; Houssein Jahamy; Sharon Valenti; Stephen P Shemes; Riad Khatib; Leonard B Johnson
Journal:  Scand J Infect Dis       Date:  2011-11-13

Review 2.  Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

Authors:  Julian Gregston Hurdle; Alexander John O'Neill; Ian Chopra
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

3.  Velvet: algorithms for de novo short read assembly using de Bruijn graphs.

Authors:  Daniel R Zerbino; Ewan Birney
Journal:  Genome Res       Date:  2008-03-18       Impact factor: 9.043

4.  Proteomic analysis of the insoluble subproteome of Clostridium difficile strain 630.

Authors:  Shailesh Jain; Robert L J Graham; Geoff McMullan; Nigel G Ternan
Journal:  FEMS Microbiol Lett       Date:  2010-09-24       Impact factor: 2.742

Review 5.  The changing epidemiology of Clostridium difficile infections.

Authors:  J Freeman; M P Bauer; S D Baines; J Corver; W N Fawley; B Goorhuis; E J Kuijper; M H Wilcox
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

6.  CcpA-mediated repression of Clostridium difficile toxin gene expression.

Authors:  Ana Antunes; Isabelle Martin-Verstraete; Bruno Dupuy
Journal:  Mol Microbiol       Date:  2010-12-28       Impact factor: 3.501

7.  Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent.

Authors:  Anjali Nandal; Cerys C O Huggins; Mark R Woodhall; Jonathan McHugh; Francisco Rodríguez-Quiñones; Michael A Quail; John R Guest; Simon C Andrews
Journal:  Mol Microbiol       Date:  2009-12-09       Impact factor: 3.501

8.  Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: a sweet tale.

Authors:  Jeffrey C Silva; Richard Denny; Craig Dorschel; Marc V Gorenstein; Guo-Zhong Li; Keith Richardson; Daniel Wall; Scott J Geromanos
Journal:  Mol Cell Proteomics       Date:  2006-01-05       Impact factor: 5.911

9.  Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole.

Authors:  Patrick M Chong; Tarah Lynch; Stuart McCorrister; Pamela Kibsey; Mark Miller; Denise Gravel; Garrett R Westmacott; Michael R Mulvey
Journal:  PLoS One       Date:  2014-01-06       Impact factor: 3.240

10.  Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers.

Authors:  Michael S M Brouwer; Adam P Roberts; Haitham Hussain; Rachel J Williams; Elaine Allan; Peter Mullany
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
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  14 in total

Review 1.  Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing.

Authors:  Zhong Peng; Dazhi Jin; Hyeun Bum Kim; Charles W Stratton; Bin Wu; Yi-Wei Tang; Xingmin Sun
Journal:  J Clin Microbiol       Date:  2017-04-12       Impact factor: 5.948

Review 2.  Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection.

Authors:  Patrizia Spigaglia
Journal:  Ther Adv Infect Dis       Date:  2016-02

3.  Impact of Subinhibitory Concentrations of Metronidazole on Morphology, Motility, Biofilm Formation and Colonization of Clostridioides difficile.

Authors:  Tri-Hanh-Dung Doan; Marie-Françoise Bernet-Camard; Sandra Hoÿs; Claire Janoir; Séverine Péchiné
Journal:  Antibiotics (Basel)       Date:  2022-05-05

Review 4.  Mechanisms and impact of antimicrobial resistance in Clostridioides difficile.

Authors:  Chetna Dureja; Abiola O Olaitan; Julian G Hurdle
Journal:  Curr Opin Microbiol       Date:  2022-01-22       Impact factor: 7.584

5.  Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.

Authors:  Aditi Deshpande; Xiaoqian Wu; Wenwen Huo; Kelli L Palmer; Julian G Hurdle
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191

Review 6.  Antimicrobial resistance in Clostridioides difficile.

Authors:  Keeley O'Grady; Daniel R Knight; Thomas V Riley
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2021-08-24       Impact factor: 3.267

7.  Molecular and Proteomic Analysis of Levofloxacin and Metronidazole Resistant Helicobacter pylori.

Authors:  Aimi Hanafi; Woon Ching Lee; Mun Fai Loke; Xinsheng Teh; Ain Shaari; Mojdeh Dinarvand; Philippe Lehours; Francis Mégraud; Alex Hwong Ruey Leow; Jamuna Vadivelu; Khean Lee Goh
Journal:  Front Microbiol       Date:  2016-12-15       Impact factor: 5.640

8.  Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile.

Authors:  Pierre Boudry; Ekaterina Semenova; Marc Monot; Kirill A Datsenko; Anna Lopatina; Ognjen Sekulovic; Maicol Ospina-Bedoya; Louis-Charles Fortier; Konstantin Severinov; Bruno Dupuy; Olga Soutourina
Journal:  MBio       Date:  2015-09-01       Impact factor: 7.867

Review 9.  Proteomics As a Tool for Studying Bacterial Virulence and Antimicrobial Resistance.

Authors:  Francisco J Pérez-Llarena; Germán Bou
Journal:  Front Microbiol       Date:  2016-03-31       Impact factor: 5.640

Review 10.  Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection.

Authors:  Simon D Baines; Mark H Wilcox
Journal:  Antibiotics (Basel)       Date:  2015-07-10
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