Boklye Kim1, Ashok Srinivasan2, Brian Sabb3, Eva L Feldman4, Rodica Pop-Busui5. 1. Department of Radiology, University of Michigan, Ann Arbor, Michigan. 2. Department of Radiology, University of Michigan, Ann Arbor, Michigan. Electronic address: ashoks@med.umich.edu. 3. Botsford General Hospital, 28050 Grand River Avenue, Farmington Hills, Michigan. 4. Department of Neurology, University of Michigan, Ann Arbor, Michigan. 5. Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan.
Abstract
OBJECTIVE: To develop a diffusion tensor imaging (DTI) protocol for assessing the sural nerve in healthy subjects. METHODS: Sural nerves in 25 controls were imaged using DTI at 3T with 6, 15, and 32 gradient directions. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were computed from nerve regions of interest co-registered with T2-weighted images. RESULTS: Coronal images with 0.5(RL)× 2.0(FH)× 0.5(AP)mm(3) resolution successfully localized the sural nerve. FA maps showed less variability with 32 directions (0.559 ± 0.071) compared to 15(0.590 ± 0.080) and 6(0.659 ± 0.109). CONCLUSIONS: Our DTI protocol was effective in imaging sural nerves in controls to establish normative FA/ADC, with potential to be used non-invasively in diseased nerves of patients.
OBJECTIVE: To develop a diffusion tensor imaging (DTI) protocol for assessing the sural nerve in healthy subjects. METHODS: Sural nerves in 25 controls were imaged using DTI at 3T with 6, 15, and 32 gradient directions. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were computed from nerve regions of interest co-registered with T2-weighted images. RESULTS: Coronal images with 0.5(RL)× 2.0(FH)× 0.5(AP)mm(3) resolution successfully localized the sural nerve. FA maps showed less variability with 32 directions (0.559 ± 0.071) compared to 15(0.590 ± 0.080) and 6(0.659 ± 0.109). CONCLUSIONS: Our DTI protocol was effective in imaging sural nerves in controls to establish normative FA/ADC, with potential to be used non-invasively in diseased nerves of patients.
Authors: Jonathan A D Farrell; Bennett A Landman; Craig K Jones; Seth A Smith; Jerry L Prince; Peter C M van Zijl; Susumu Mori Journal: J Magn Reson Imaging Date: 2007-09 Impact factor: 4.813
Authors: C R Meyer; J L Boes; B Kim; P H Bland; K R Zasadny; P V Kison; K Koral; K A Frey; R L Wahl Journal: Med Image Anal Date: 1997-04 Impact factor: 8.545