Qiong Hong1, Jianhua Xu2, Shengqian Xu3, Li Lian3, Mingming Zhang3, Changhai Ding4. 1. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. 2. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. xujianhua86@yahoo.cn. 3. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. 4. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People's Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
Abstract
OBJECTIVE: The aim of this study was to describe the associations between serum levels of 25-hydroxyvitamin D [25(OH)D] and disease activity, inflammatory cytokines and bone loss/erosions in patients with RA. METHODS: The study included 130 patients with RA and 80 healthy controls. Serum 25(OH)D, IL-17 and IL-23 levels were detected by ELISA. Radiographic bone erosion was assessed using the van der Heijde modified Sharp score and BMD was measured using DXA. RESULTS: There were no significant differences in age, gender and BMI between the RA and control groups. Serum level of 25(OH)D was markedly lower in the RA group than in the control group [43.12 nmol/l (s.d. 15.59) vs 57.93 (15.95), P < 0.01]. In RA patients, 25(OH)D levels were significantly and negatively associated with clinical parameters of disease activity including swollen joint count, tender joint count, joint pain degree, morning stiffness time and HAQ score and laboratory measures including platelets and ESR after adjustment for gender, age and BMI. They were also negatively associated with serum levels of IL-17 and IL-23. While 25(OH)D levels were not associated with radiographic bone erosions of RA, they were significantly lower in those with osteopenia and osteoporosis than in those with normal BMD (P < 0.01). CONCLUSION: 25(OH)D levels were reduced in patients with RA and were negatively associated with disease activity, IL-17/IL-23 and bone loss in RA. These suggest that vitamin D deficiency may play a role in the aetiology of RA.
OBJECTIVE: The aim of this study was to describe the associations between serum levels of 25-hydroxyvitamin D [25(OH)D] and disease activity, inflammatory cytokines and bone loss/erosions in patients with RA. METHODS: The study included 130 patients with RA and 80 healthy controls. Serum 25(OH)D, IL-17 and IL-23 levels were detected by ELISA. Radiographic bone erosion was assessed using the van der Heijde modified Sharp score and BMD was measured using DXA. RESULTS: There were no significant differences in age, gender and BMI between the RA and control groups. Serum level of 25(OH)D was markedly lower in the RA group than in the control group [43.12 nmol/l (s.d. 15.59) vs 57.93 (15.95), P < 0.01]. In RApatients, 25(OH)D levels were significantly and negatively associated with clinical parameters of disease activity including swollen joint count, tender joint count, joint pain degree, morning stiffness time and HAQ score and laboratory measures including platelets and ESR after adjustment for gender, age and BMI. They were also negatively associated with serum levels of IL-17 and IL-23. While 25(OH)D levels were not associated with radiographic bone erosions of RA, they were significantly lower in those with osteopenia and osteoporosis than in those with normal BMD (P < 0.01). CONCLUSION: 25(OH)D levels were reduced in patients with RA and were negatively associated with disease activity, IL-17/IL-23 and bone loss in RA. These suggest that vitamin D deficiency may play a role in the aetiology of RA.
Authors: Sâmia Araújo de Sousa Studart; Ana Caroline Rocha Melo Leite; Aryana Lushese Lima Feitosa Marinho; Ana Carolina Matias Dinelly Pinto; Carlos Nobre Rabelo Júnior; Rodolfo de Melo Nunes; Hermano Alexandre Lima Rocha; Francisco Airton Castro Rocha Journal: Rheumatol Int Date: 2015-05-20 Impact factor: 2.631
Authors: Martin P Playford; Amit K Dey; Claudia Zierold; Aditya A Joshi; Frank Blocki; Fabrizio Bonelli; Justin A Rodante; Charlotte L Harrington; Joshua P Rivers; Youssef A Elnabawi; Marcus Y Chen; Mark A Ahlman; Heather L Teague; Nehal N Mehta Journal: Atherosclerosis Date: 2019-08-17 Impact factor: 5.162
Authors: Alberto Lo Gullo; Giuseppe Mandraffino; Gianluca Bagnato; Caterina Oriana Aragona; Egidio Imbalzano; Angela D'Ascola; Francesco Rotondo; Antonella Cinquegrani; Enricomaria Mormina; Carlo Saitta; Antonio Giovanni Versace; Maria Adriana Sardo; Renato Lo Gullo; Saverio Loddo; Antonino Saitta Journal: PLoS One Date: 2015-08-04 Impact factor: 3.240