PURPOSE: Angiogenesis is an essential process for the expansion of multiple myeloma (MM). Angiopoietin-2 (Ang-2), Ang-1 and their receptor possess important roles in this procedure. The aim of the study was to measure serum levels of Ang-2 along with known markers of angiogenesis and to estimate their prognostic impact on the survival. METHODS: Bone marrow microvascular density (MVD), estimated by CD31, and circulating levels of known angiogenic factors Ang-2, interleukin-6, soluble CD105 and platelet-derived growth factor-AB, measured by ELISA, were measured in 77 newly diagnosed patients with active MM and in 57 of them who responded to chemotherapy. RESULTS: All measured parameters were increased in MM patients, were also increasing in advanced disease and decreased after effective treatment. Ang-2 correlated positively with the other angiogenic factors and MVD. Moreover, Ang-2 values above the median were accompanied by worse survival. CONCLUSION: Ang-2 correlates strongly with the angiogenic process and its serum levels are importantly prognostic for survival, highlighting the role of angiopoietins pathway in the biology of MM.
PURPOSE: Angiogenesis is an essential process for the expansion of multiple myeloma (MM). Angiopoietin-2 (Ang-2), Ang-1 and their receptor possess important roles in this procedure. The aim of the study was to measure serum levels of Ang-2 along with known markers of angiogenesis and to estimate their prognostic impact on the survival. METHODS: Bone marrow microvascular density (MVD), estimated by CD31, and circulating levels of known angiogenic factors Ang-2, interleukin-6, soluble CD105 and platelet-derived growth factor-AB, measured by ELISA, were measured in 77 newly diagnosed patients with active MM and in 57 of them who responded to chemotherapy. RESULTS: All measured parameters were increased in MM patients, were also increasing in advanced disease and decreased after effective treatment. Ang-2 correlated positively with the other angiogenic factors and MVD. Moreover, Ang-2 values above the median were accompanied by worse survival. CONCLUSION:Ang-2 correlates strongly with the angiogenic process and its serum levels are importantly prognostic for survival, highlighting the role of angiopoietins pathway in the biology of MM.
Authors: George Tsirakis; Constantina A Pappa; Peggy Kanellou; Maria A Stratinaki; Athina Xekalou; Fotios E Psarakis; George Sakellaris; Athanasios Alegakis; Efstathios N Stathopoulos; Michael G Alexandrakis Journal: Hematol Oncol Date: 2011-09-14 Impact factor: 5.271
Authors: Constantina A Pappa; George Tsirakis; Panagiotis Samiotakis; Maria Tsigaridaki; Athanasios Alegakis; Nectaria Goulidaki; Michael G Alexandrakis Journal: Cancer Invest Date: 2013-06-11 Impact factor: 2.176
Authors: C A Pappa; M G Alexandrakis; A Boula; F E Psarakis; A Kolovou; V Bantouna; E Stavroulaki; G Tsirakis Journal: Hematol Oncol Date: 2013-04-11 Impact factor: 5.271