| Literature DB >> 24904168 |
Yu Jiang1,2,3, Min Xie4, Wenbin Chen4, Richard Talbot5, Jillian F Maddox6, Thomas Faraut7, Chunhua Wu8, Donna M Muzny9, Yuxiang Li4, Wenguang Zhang1,10,11, Jo-Ann Stanton12, Rudiger Brauning13, Wesley C Barris2, Thibaut Hourlier14,15, Bronwen L Aken14,15, Stephen M J Searle14, David L Adelson2, Chao Bian4, Graham R Cam2, Yulin Chen3, Shifeng Cheng4, Udaya DeSilva2, Karen Dixen16, Yang Dong1, Guangyi Fan4, Ian R Franklin2, Shaoyin Fu10, Rui Guan4, Margaret A Highland17,18, Michael E Holder9, Guodong Huang4, Aaron B Ingham2, Shalini N Jhangiani9, Divya Kalra9, Christie L Kovar9, Sandra L Lee9, Weiqing Liu4, Xin Liu4, Changxin Lu4, Tian Lv4, Tittu Mathew9, Sean McWilliam2, Moira Menzies2, Shengkai Pan4, David Robelin7, Bertrand Servin7, David Townley2, Wenliang Wang4, Bin Wei4,19, Stephen N White17,18, Xinhua Yang4, Chen Ye4, Yaojing Yue20, Peng Zeng4, Qing Zhou4, Jacob B Hansen16, Karsten Kristensen21, Richard A Gibbs9, Paul Flicek15, Christopher C Warkup22, Huw E Jones22, V Hutton Oddy23, Frank W Nicholas24, John C McEwan13, James Kijas2, Jun Wang4,21,25,26, Kim C Worley9, Alan L Archibald27, Noelle Cockett8, Xun Xu4, Wen Wang1, Brian P Dalrymple2.
Abstract
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.Entities:
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Year: 2014 PMID： 24904168 PMCID： PMC4157056 DOI： 10.1126/science.1252806
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728