| Literature DB >> 24901948 |
Hana Zelová1, Zuzana Hanáková, Zuzana Čermáková, Karel Šmejkal, Stefano Dalĺ Acqua, Petr Babula, Josef Cvačka, Jan Hošek.
Abstract
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.Entities:
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Year: 2014 PMID： 24901948 DOI： 10.1021/np401025f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050