Philippe Morlat1, Caroline Roussillon, Sandrine Henard, Dominique Salmon, Fabrice Bonnet, Patrice Cacoub, Aurore Georget, Albertine Aouba, Eric Rosenthal, Thierry May, Marie Chauveau, Bilghissa Diallo, Dominique Costagliola, Geneviève Chene. 1. aINSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques bService de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux cUniversity Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux dService de Maladies Infectieuses, Hôpital Brabois, Vandoeuvre-Les-Nancy eUnité de Pathologie Infectieuse, Pôle Médecine, Hôpital Cochin, AP-HP fUniversité Paris Descartes gDepartment of Internal Medicine and Immunology, AP-HP Hôpital La Pitié-Salpêtrière hDépartement Hospitalo-universitaire I2B, UPMC Univ Paris 06, UMR 7211, Paris iINSERM-CépiDC, Le Kremlin-Bicêtre jService de Médecine Interne, Hôpital de l'Archet kUniversité de Nice-Sophia Antipolis, Nice lService des Maladies Infectieuses et Tropicales, Hôpital Purpan, Toulouse mService des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord Val de Seine nUniversité Paris 7 oINSERM, UMR-S 1136 pSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Paris qCHU de Bordeaux, Pole de Santé Publique, Bordeaux, France.
Abstract
OBJECTIVE: The Mortalité 2010 survey aimed at describing the causes of death among HIV-infected patients in France in 2010 and their evolution since 2000. DESIGN AND METHODS: A national sample of clinical sites, providing HIV care and treatment, notified and documented deaths using a standardized questionnaire. RESULTS: The 90 participating wards notified 728 deaths. Median age at death was 50 years (interquartile range 45-58) and 75% were men. The main underlying causes of death were AIDS-related (25% in 2010 vs. 36% in 2005 and 47% in 2000), non-AIDS non-viral hepatitis-related malignancy (22 vs. 17 and 11%), liver-related (11 vs. 15 and 13%), cardiovascular diseases (10 vs. 8 and 7%) and non-AIDS-related infections (9 vs. 4 and 7%). Malignancies (AIDS and non-AIDS-related) accounted for a third of all causes of death. AIDS accounted for 33% of all causes of death among patients mono-infected with HIV vs. only 13% among those co-infected with hepatitis B virus or hepatitis C virus. CONCLUSION: In 2010, 25% of the causes of death among HIV-infected patients remained AIDS-related. Improved screening and earlier HIV treatment should lead to a smaller proportion of deaths due to AIDS. The majority of patients died of various causes, whereas their HIV infection was well controlled under treatment. Improving case management of HIV-infected patients should include a multidisciplinary approach (prevention, screening, treatment), especially in oncology. Smoking cessation should be a priority goal.
OBJECTIVE: The Mortalité 2010 survey aimed at describing the causes of death among HIV-infectedpatients in France in 2010 and their evolution since 2000. DESIGN AND METHODS: A national sample of clinical sites, providing HIV care and treatment, notified and documented deaths using a standardized questionnaire. RESULTS: The 90 participating wards notified 728 deaths. Median age at death was 50 years (interquartile range 45-58) and 75% were men. The main underlying causes of death were AIDS-related (25% in 2010 vs. 36% in 2005 and 47% in 2000), non-AIDS non-viral hepatitis-related malignancy (22 vs. 17 and 11%), liver-related (11 vs. 15 and 13%), cardiovascular diseases (10 vs. 8 and 7%) and non-AIDS-related infections (9 vs. 4 and 7%). Malignancies (AIDS and non-AIDS-related) accounted for a third of all causes of death. AIDS accounted for 33% of all causes of death among patients mono-infected with HIV vs. only 13% among those co-infected with hepatitis B virus or hepatitis C virus. CONCLUSION: In 2010, 25% of the causes of death among HIV-infectedpatients remained AIDS-related. Improved screening and earlier HIV treatment should lead to a smaller proportion of deaths due to AIDS. The majority of patients died of various causes, whereas their HIV infection was well controlled under treatment. Improving case management of HIV-infectedpatients should include a multidisciplinary approach (prevention, screening, treatment), especially in oncology. Smoking cessation should be a priority goal.
Authors: Lesley S Park; Raúl U Hernández-Ramírez; Michael J Silverberg; Kristina Crothers; Robert Dubrow Journal: AIDS Date: 2016-01 Impact factor: 4.177
Authors: Aaron P Thrift; Jennifer R Kramer; Christine M Hartman; Kathryn Royse; Peter Richardson; Yongquan Dong; Suchismita Raychaudhury; Roxanne Desiderio; Dina Sanchez; Sharmila Anandasabapathy; Donna L White; Elizabeth Y Chiao Journal: J Acquir Immune Defic Syndr Date: 2019-07-01 Impact factor: 3.731