Literature DB >> 24900943

Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases.

Atsuko Nakanishi1, Yoko Wada1, Yasuko Kitagishi1, Satoru Matsuda1.   

Abstract

Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging.

Entities:  

Keywords:  AKT; PI3K; PPAR; PTEN; ROS; SIRT1; WRN; cell signaling

Year:  2014        PMID： 24900943      PMCID： PMC4037312          DOI： 10.14336/AD.2014.0500203

Source DB:  PubMed          Journal:  Aging Dis        ISSN： 2152-5250            Impact factor:   6.745


  52 in total

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Review 7.  Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.

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