Literature DB >> 26617972

Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.

Nikunj Bhatt1, Nisarg Soni1, Yeong Su Ha1, Woonghee Lee1, Darpan N Pandya1, Swarbhanu Sarkar1, Jung Young Kim2, Hochun Lee3, Sun Hee Kim4, Gwang Il An2, Jeongsoo Yoo1.   

Abstract

A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, (64)Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

Entities:  

Keywords:  Bifunctional chelator; phosphonate pendant arms; propylene cross bridge; radiopharmaceuticals

Year:  2015        PMID： 26617972      PMCID： PMC4645244          DOI： 10.1021/acsmedchemlett.5b00362

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  21 in total

1.  Revival of TE2A; a better chelate for Cu(II) ions than TETA?

Authors:  Darpan N Pandya; Jung Young Kim; Jeong Chan Park; Hochun Lee; Prasad B Phapale; Wonjung Kwak; Tae Hyun Choi; Gi Jeong Cheon; Young-Ran Yoon; Jeongsoo Yoo
Journal:  Chem Commun (Camb)       Date:  2010-03-23       Impact factor: 6.222

2.  The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals.

Authors:  Paul S Donnelly
Journal:  Dalton Trans       Date:  2011-01-04       Impact factor: 4.390

3.  An extremely efficient three-component reaction of aldehydes/ketones, amines, and phosphites (Kabachnik-Fields reaction) for the synthesis of alpha-aminophosphonates catalyzed by magnesium perchlorate.

Authors:  Srikant Bhagat; Asit K Chakraborti
Journal:  J Org Chem       Date:  2007-01-25       Impact factor: 4.354

4.  A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(ii) binding for radiopharmaceutical applications.

Authors:  Dannon J Stigers; Riccardo Ferdani; Gary R Weisman; Edward H Wong; Carolyn J Anderson; James A Golen; Curtis Moore; Arnold L Rheingold
Journal:  Dalton Trans       Date:  2009-12-15       Impact factor: 4.390

5.  Cyclam (1,4,8,11-tetraazacyclotetradecane) with one methylphosphonate pendant arm: a new ligand for selective copper(ii) binding.

Authors:  Silvia Füzerová; Jan Kotek; Ivana Císarová; Petr Hermann; Koen Binnemans; Ivan Lukes
Journal:  Dalton Trans       Date:  2005-07-26       Impact factor: 4.390

6.  Propylene cross-bridged macrocyclic bifunctional chelator: a new design for facile bioconjugation and robust (64)Cu complex stability.

Authors:  Darpan N Pandya; Nikunj Bhatt; Gwang Il An; Yeong Su Ha; Nisarg Soni; Hochun Lee; Yong Jin Lee; Jung Young Kim; Woonghee Lee; Heesu Ahn; Jeongsoo Yoo
Journal:  J Med Chem       Date:  2014-08-26       Impact factor: 7.446

7.  Synthesis, Cu(II) complexation, 64Cu-labeling and biological evaluation of cross-bridged cyclam chelators with phosphonate pendant arms.

Authors:  Riccardo Ferdani; Dannon J Stigers; Ashley L Fiamengo; Lihui Wei; Barbara T Y Li; James A Golen; Arnold L Rheingold; Gary R Weisman; Edward H Wong; Carolyn J Anderson
Journal:  Dalton Trans       Date:  2011-12-15       Impact factor: 4.390

8.  Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator.

Authors:  Jennifer E Sprague; Yijie Peng; Xiankai Sun; Gary R Weisman; Edward H Wong; Samuel Achilefu; Carolyn J Anderson
Journal:  Clin Cancer Res       Date:  2004-12-15       Impact factor: 12.531

9.  Pycup--a bifunctional, cage-like ligand for (64)Cu radiolabeling.

Authors:  Eszter Boros; Elena Rybak-Akimova; Jason P Holland; Tyson Rietz; Nicholas Rotile; Francesco Blasi; Helen Day; Reza Latifi; Peter Caravan
Journal:  Mol Pharm       Date:  2013-12-11       Impact factor: 4.939

10.  High thermodynamic stability and extraordinary kinetic inertness of copper(II) complexes with 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid): example of a rare isomerism between kinetically inert penta- and hexacoordinated copper(II) complexes.

Authors:  Jan Kotek; Premysl Lubal; Petr Hermann; Ivana Císarová; Ivan Lukes; Tomás Godula; Ivona Svobodová; Petr Táborský; Josef Havel
Journal:  Chemistry       Date:  2003-01-03       Impact factor: 5.236
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