Literature DB >> 20485810

Modified siRNAs for the study of the PAZ domain.

Alvaro Somoza1, Montserrat Terrazas, Ramón Eritja.   

Abstract

Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

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Year:  2010        PMID： 20485810     DOI： 10.1039/c003221b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Guide Strand 3'-End Modifications Regulate siRNA Specificity.

Authors:  Rachel A P Valenzuela; Kazumitsu Onizuka; Alexi A Ball-Jones; Tiannan Hu; Scott R Suter; Peter A Beal
Journal:  Chembiochem       Date:  2016-11-07       Impact factor: 3.164

2.  Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.

Authors:  Maria Gaglione; Nicoletta Potenza; Giovanni Di Fabio; Valeria Romanucci; Nicola Mosca; Aniello Russo; Ettore Novellino; Sandro Cosconati; Anna Messere
Journal:  ACS Med Chem Lett       Date:  2012-11-16       Impact factor: 4.345

3.  Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles.

Authors:  Christian Posch; Alfonso Latorre; Michelle B Crosby; Anna Celli; Ana Latorre; Igor Vujic; Martina Sanlorenzo; Gary A Green; Jingly Weier; Mitchell Zekhtser; Jeffrey Ma; Gabriela Monico; Devron H Char; Denis Jusufbegovic; Klemens Rappersberger; Álvaro Somoza; Susana Ortiz-Urda
Journal:  Biomed Microdevices       Date:  2015-02       Impact factor: 2.838

4.  In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference.

Authors:  Mahmoud Kandeel; Yukio Kitade
Journal:  J Comput Aided Mol Des       Date:  2013-07-23       Impact factor: 3.686

5.  Synthesis and gene silencing properties of siRNAs containing terminal amide linkages.

Authors:  Maria Gaglione; M Emilia Mercurio; Nicoletta Potenza; Nicola Mosca; Aniello Russo; Ettore Novellino; Sandro Cosconati; Anna Messere
Journal:  Biomed Res Int       Date:  2014-03-26       Impact factor: 3.411

6.  Bioenergetics and gene silencing approaches for unraveling nucleotide recognition by the human EIF2C2/Ago2 PAZ domain.

Authors:  Mahmoud Kandeel; Abdullah Al-Taher; Remi Nakashima; Tomoya Sakaguchi; Ali Kandeel; Yuki Nagaya; Yoshiaki Kitamura; Yukio Kitade
Journal:  PLoS One       Date:  2014-05-02       Impact factor: 3.240

7.  Computational analysis of siRNA recognition by the Ago2 PAZ domain and identification of the determinants of RNA-induced gene silencing.

Authors:  Mahmoud Kandeel; Yukio Kitade
Journal:  PLoS One       Date:  2013-02-18       Impact factor: 3.240

8.  siRNAmod: A database of experimentally validated chemically modified siRNAs.

Authors:  Showkat Ahmad Dar; Anamika Thakur; Abid Qureshi; Manoj Kumar
Journal:  Sci Rep       Date:  2016-01-28       Impact factor: 4.379

9.  Exploring PAZ/3'-overhang interaction to improve siRNA specificity. A combined experimental and modeling study.

Authors:  Adele Alagia; Andreia F Jorge; Anna Aviñó; Tânia F G G Cova; Ramon Crehuet; Santiago Grijalvo; Alberto A C C Pais; Ramon Eritja
Journal:  Chem Sci       Date:  2018-01-15       Impact factor: 9.825

10.  Synthesis of oligonucleotides carrying thiol groups using a simple reagent derived from threoninol.

Authors:  Sonia Pérez-Rentero; Santiago Grijalvo; Rubén Ferreira; Ramon Eritja
Journal:  Molecules       Date:  2012-08-24       Impact factor: 4.411
  10 in total

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