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Literature DB >> 24900530

Lipidated peptidomimetics with improved antimicrobial activity.

Yaogang Hu¹, Mohamad Nassir Amin¹, Shruti Padhee¹, Rongsheng E Wang¹, Qiao Qiao¹, Ge Bai¹, Yaqong Li¹, Archana Mathew¹, Chuanhai Cao¹, Jianfeng Cai¹.

Abstract

We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

Keywords: antimicrobial peptides; drug resistance; lipidation; peptidomimetics; α-AApeptides

Year: 2012 PMID： 24900530 PMCID： PMC4025737 DOI： 10.1021/ml3001215

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

33 in total

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Authors: Alexandra K Marr; William J Gooderham; Robert Ew Hancock
Journal: Curr Opin Pharmacol Date: 2006-08-04 Impact factor: 5.547

2. Mimicking helical antibacterial peptides with nonpeptidic folding oligomers.

Authors: Aude Violette; Sylvie Fournel; Karen Lamour; Olivier Chaloin; Benoit Frisch; Jean-Paul Briand; Henri Monteil; Gilles Guichard
Journal: Chem Biol Date: 2006-05

3. Ultrashort antibacterial and antifungal lipopeptides.

Authors: Arik Makovitzki; Dorit Avrahami; Yechiel Shai
Journal: Proc Natl Acad Sci U S A Date: 2006-10-12 Impact factor: 11.205

4. Non-hemolytic α-AApeptides as antimicrobial peptidomimetics.

Authors: Shruti Padhee; Yaogang Hu; Youhong Niu; Ge Bai; Haifan Wu; Frankie Costanza; Leigh West; Lacey Harrington; Lindsey N Shaw; Chuanhai Cao; Jianfeng Cai
Journal: Chem Commun (Camb) Date: 2011-07-21 Impact factor: 6.222

5. In vitro antibacterial properties of pexiganan, an analog of magainin.

Authors: Y Ge; D L MacDonald; K J Holroyd; C Thornsberry; H Wexler; M Zasloff
Journal: Antimicrob Agents Chemother Date: 1999-04 Impact factor: 5.191

6. Antibacterial mechanism of action of arylamide foldamers.

Authors: Bruk Mensa; Yong Ho Kim; Sungwook Choi; Richard Scott; Gregory A Caputo; William F DeGrado
Journal: Antimicrob Agents Chemother Date: 2011-08-15 Impact factor: 5.191

Review 7. De novo designed synthetic mimics of antimicrobial peptides.

Authors: Richard W Scott; William F DeGrado; Gregory N Tew
Journal: Curr Opin Biotechnol Date: 2008-11-17 Impact factor: 9.740

8. Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides.

Authors: Nathaniel P Chongsiriwatana; James A Patch; Ann M Czyzewski; Michelle T Dohm; Andrey Ivankin; David Gidalevitz; Ronald N Zuckermann; Annelise E Barron
Journal: Proc Natl Acad Sci U S A Date: 2008-02-19 Impact factor: 11.205

9. Antimicrobial lipopolypeptides composed of palmitoyl Di- and tricationic peptides: in vitro and in vivo activities, self-assembly to nanostructures, and a plausible mode of action.

Authors: Arik Makovitzki; Jonathan Baram; Yechiel Shai
Journal: Biochemistry Date: 2008-09-11 Impact factor: 3.162

10. Acylation of SC4 dodecapeptide increases bactericidal potency against Gram-positive bacteria, including drug-resistant strains.

Authors: Nathan A Lockwood; Judith R Haseman; Matthew V Tirrell; Kevin H Mayo
Journal: Biochem J Date: 2004-02-15 Impact factor: 3.857

19 in total

1. Toward Hemocompatible Self-assembling Antimicrobial Nanofibers: Understanding the Synergistic Effect of Supramolecular Structure and PEGylation on Hemocompatibility.

Authors: Dawei Xu; Qian Ran; Yang Xiang; Jiang Linhai; Britannia M Smith; Fadi Bou-Abdallah; Reidar Lund; Zhongjun Li; He Dong
Journal: RSC Adv Date: 2016-01-26 Impact factor: 3.361

2. Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria.

Authors: Alekhya Nimmagadda; Xuan Liu; Peng Teng; Ma Su; Yaqiong Li; Qiao Qiao; Nawal K Khadka; Xiaoting Sun; Jianjun Pan; Hai Xu; Qi Li; Jianfeng Cai
Journal: Biomacromolecules Date: 2016-12-08 Impact factor: 6.988

3. The development of antimicrobial a-AApeptides that suppress proinflammatory immune responses.

Authors: Shruti Padhee; Christina Smith; Haifan Wu; Yaqiong Li; Namitha Manoj; Qiao Qiao; Zoya Khan; Chuanhai Cao; Hang Yin; Jianfeng Cai
Journal: Chembiochem Date: 2014-03-21 Impact factor: 3.164

Review 4. Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

Authors: Natalia Molchanova; Paul R Hansen; Henrik Franzyk
Journal: Molecules Date: 2017-08-29 Impact factor: 4.411

5. Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.

Authors: Venkateswarlu Yarlagadda; Mohini M Konai; Goutham B Manjunath; Chandradhish Ghosh; Jayanta Haldar
Journal: J Antibiot (Tokyo) Date: 2014-10-29 Impact factor: 2.649

Review 6. Antimicrobial AApeptides.

Authors: Peng Sang; Yan Shi; Peng Teng; Annie Cao; Hai Xu; Qi Li; Jianfeng Cai
Journal: Curr Top Med Chem Date: 2017 Impact factor: 3.295