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Literature DB >> 24900497

Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators.

Keith Ó Proinsias¹, Maciej Giedyk¹, Iraida G Sharina², Emil Martin², Dorota Gryko¹.

Abstract

Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)2Cbi.

Entities: Chemical

Keywords: aminolysis; cobinamide; soluble guanyl cyclase; vitamin B12

Year: 2012 PMID： 24900497 PMCID： PMC4025757 DOI： 10.1021/ml300060n

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

12 in total

1. YC-1, a novel activator of platelet guanylate cyclase.

Authors: F N Ko; C C Wu; S C Kuo; F Y Lee; C M Teng
Journal: Blood Date: 1994-12-15 Impact factor: 22.113

2. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

Authors: C A Gruetter; B K Barry; D B McNamara; D Y Gruetter; P J Kadowitz; L Ignarro
Journal: J Cyclic Nucleotide Res Date: 1979

Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators.

1. YC-1, a novel activator of platelet guanylate cyclase.

2. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

3. Selective modifications of hydrophobic vitamin B12 derivatives at c-and d-positions.

4. New hydrophobic vitamin B12 derivatives via ring-opening reactions of c-lactone.

Review 5. Nitric oxide: a unique endogenous signaling molecule in vascular biology.

6. Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.

7. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase.

Review 8. NO- and haem-independent soluble guanylate cyclase activators.

Review 9. Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.

10. NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272.

1. Vitamin B₁₂ derivatives as activators of soluble guanylyl cyclase.