| Literature DB >> 22991977 |
Keith ó Proinsias1, Daniel T Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L Sessler, Dorota Gryko.
Abstract
Various newly prepared and previously known vitamin B₁₂ derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.Entities:
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Year: 2012 PMID： 22991977 PMCID： PMC3671888 DOI： 10.1021/jm3006959
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446