Literature DB >> 24900465

Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.

Raghavan Rajagopalan1, Tien-Sung Lin2, Amolkumar S Karwa1, Amruta R Poreddy1, Bethel Asmelash1, Richard B Dorshow1.   

Abstract

Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance (ESR) spectroscopy. Among the diarylamines, the most potent compounds were acridan (4) and 9-phenylacridan (5), with IC50 values of 0.68 μM and 0.17 μM, respectively.

Entities:  

Keywords:  Diarylamines; ESR; ROS; photosensitizers; radicals; type 1; type 2

Year:  2012        PMID： 24900465      PMCID： PMC4025672          DOI： 10.1021/ml200266v

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  12 in total

Review 1.  Photodynamic therapy for the treatment of cutaneous neoplasia, inflammatory disorders, and photoaging.

Authors:  Emily Tierney; Allison Barker; Jennifer Ahdout; C William Hanke; Ronald L Moy; David J Kouba
Journal:  Dermatol Surg       Date:  2009-03-20       Impact factor: 3.398

2.  Antioxidant activity of synthetic diarylamines: a mitochondrial and cellular approach.

Authors:  Diana Pinto-Basto; João P Silva; Maria-João R P Queiroz; António J Moreno; Olga P Coutinho
Journal:  Mitochondrion       Date:  2008-10-14       Impact factor: 4.160

3.  Ionization of cyclic aromatic amines by free electron transfer: products are governed by molecule flexibility.

Authors:  Ortwin Brede; Andrej Maroz; Ralf Hermann; Sergej Naumov
Journal:  J Phys Chem A       Date:  2005-09-15       Impact factor: 2.781

4.  Type 1 phototherapeutic agents, part I: preparation and cancer cell viability studies of novel photolabile sulfenamides.

Authors:  Amolkumar S Karwa; Amruta R Poreddy; Bethel Asmelash; Tien-Sung Lin; Richard B Dorshow; Raghavan Rajagopalan
Journal:  ACS Med Chem Lett       Date:  2011-09-13       Impact factor: 4.345

5.  Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts.

Authors:  Aldwin Suryo Rahmanto; Philip E Morgan; Clare L Hawkins; Michael J Davies
Journal:  Free Radic Biol Med       Date:  2010-08-12       Impact factor: 7.376

6.  In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine.

Authors:  G Viola; G Miolo; D Vedaldi; F Dall'Acqua
Journal:  Farmaco       Date:  2000-03

Review 7.  Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs.

Authors:  P Wardman; M F Dennis; S A Everett; K B Patel; M R Stratford; M Tracy
Journal:  Biochem Soc Symp       Date:  1995

8.  The red cell as a sensitive target for activated toxic arylamines.

Authors:  P Eyer
Journal:  Arch Toxicol Suppl       Date:  1983

Review 9.  Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer?

Authors:  Heike J Nyst; I Bing Tan; Fiona A Stewart; Alfons J M Balm
Journal:  Photodiagnosis Photodyn Ther       Date:  2009-05-05       Impact factor: 3.631

10.  Identification of nitroxide radioprotectors.

Authors:  S M Hahn; L Wilson; C M Krishna; J Liebmann; W DeGraff; J Gamson; A Samuni; D Venzon; J B Mitchell
Journal:  Radiat Res       Date:  1992-10       Impact factor: 2.841
View more
  1 in total

1.  Laser-Induced Antibacterial Activity of Novel Symmetric Carbazole-Based Ethynylpyridine Photosensitizers.

Authors:  Lin-Lin Chen; Mei-Ling Zheng; Yong-Chao Zheng; Feng Jin; Qian-Qian Chai; Yuan-Yuan Zhao; Xian-Wei Meng; Yan-Hong Liu; Xuan-Ming Duan
Journal:  ACS Omega       Date:  2018-04-03
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.