Literature DB >> 24900271

Type 1 phototherapeutic agents, part I: preparation and cancer cell viability studies of novel photolabile sulfenamides.

Amolkumar S Karwa1, Amruta R Poreddy1, Bethel Asmelash1, Tien-Sung Lin2, Richard B Dorshow1, Raghavan Rajagopalan1.   

Abstract

Novel type 1 phototherapeutic agents based on compounds containing S-N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.

Entities:  

Keywords:  ESR; ROS; Sulfenamides; photosensitizers; radicals; type 1; type 2

Year:  2011        PMID： 24900271      PMCID： PMC4018100          DOI： 10.1021/ml2001483

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  15 in total

Review 1.  A review of progress in clinical photodynamic therapy.

Authors:  Z Huang
Journal:  Technol Cancer Res Treat       Date:  2005-06

2.  Cellular and molecular effects of the liposomal mTHPC derivative Foslipos in prostate carcinoma cells in vitro.

Authors:  Emina Besic Gyenge; Seraina Hiestand; Susanna Graefe; Heinrich Walt; Caroline Maake
Journal:  Photodiagnosis Photodyn Ther       Date:  2011-06       Impact factor: 3.631

3.  A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability.

Authors:  M Ishiyama; Y Miyazono; K Sasamoto; Y Ohkura; K Ueno
Journal:  Talanta       Date:  1997-07       Impact factor: 6.057

Review 4.  Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy.

Authors:  Aisling E O'Connor; William M Gallagher; Annette T Byrne
Journal:  Photochem Photobiol       Date:  2009-08-03       Impact factor: 3.421

5.  Photodynamic therapy for Barrett's oesophagus and oesophageal carcinoma-How I do it.

Authors:  D Mitton; R Ackroyd
Journal:  Photodiagnosis Photodyn Ther       Date:  2006-05-02       Impact factor: 3.631

Review 6.  Adventures in sulfur-nitrogen chemistry.

Authors:  Franklin A Davis
Journal:  J Org Chem       Date:  2006-11-24       Impact factor: 4.354

7.  Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy.

Authors:  Stephen M Hahn; Mary E Putt; James Metz; Daniel B Shin; Elizabeth Rickter; Chandrakala Menon; Debbie Smith; Eli Glatstein; Douglas L Fraker; Theresa M Busch
Journal:  Clin Cancer Res       Date:  2006-09-15       Impact factor: 12.531

Review 8.  Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs.

Authors:  P Wardman; M F Dennis; S A Everett; K B Patel; M R Stratford; M Tracy
Journal:  Biochem Soc Symp       Date:  1995

9.  Detection of free radicals by microdialysis/spin trapping EPR following focal cerebral ischemia-reperfusion and a cautionary note on the stability of 5,5-dimethyl-1-pyrroline N-oxide (DMPO).

Authors:  L L Dugan; T S Lin; Y Y He; C Y Hsu; D W Choi
Journal:  Free Radic Res       Date:  1995-07

10.  Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis.

Authors:  T Momma; M R Hamblin; H C Wu; T Hasan
Journal:  Cancer Res       Date:  1998-12-01       Impact factor: 12.701
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  2 in total

1.  Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.

Authors:  Raghavan Rajagopalan; Tien-Sung Lin; Amolkumar S Karwa; Amruta R Poreddy; Bethel Asmelash; Richard B Dorshow
Journal:  ACS Med Chem Lett       Date:  2012-02-16       Impact factor: 4.345

2.  A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy.

Authors:  Xiaoxi Zhuang; Xiaowei Ma; Xiangdong Xue; Qiao Jiang; Linlin Song; Luru Dai; Chunqiu Zhang; Shubin Jin; Keni Yang; Baoquan Ding; Paul C Wang; Xing-Jie Liang
Journal:  ACS Nano       Date:  2016-03-10       Impact factor: 15.881
  2 in total

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