| Literature DB >> 24900274 |
Hua Chen1, Qingmei Yin1, Chunxiao Li1, Enkai Wang1, Fang Gao1, Xiaobo Zhang1, Zhi Yin1, Sinan Wei1, Xiaoliu Li2, Ming Meng1, Pingzhu Zhang1, Na Li1, Jinchao Zhang1.
Abstract
Several novel C-pseudonucleosides bearing thiazolidin-4-one were synthesized by one-pot three-component condensation using unprotected sugar aldehyde at room temperature, and their effects on T cells, B cells, the cytokine secretion of IL-2, IL-4, and IFN-γ, T cell-associated molecules (CD3, CD4, CD8), and B cell-associated molecules (CD19) were first evaluated. The experimental data demonstrated that such thiazolidin-4-one C-pseudonucleosides hold potential as immunostimulating agents.Entities:
Keywords: C-pseudonucleosides; Immunostimulating agents; thiazolidin-4-one
Year: 2011 PMID： 24900274 PMCID： PMC4018124 DOI： 10.1021/ml200155k
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345