Literature DB >> 24900222

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex.

Luigi Messori1, Angela Casini2, Chiara Gabbiani1, Elena Michelucci3, Leticia Cubo4, Carla Ríos-Luci5, José M Padrón5, Carmen Navarro-Ranninger4, Adoracion G Quiroga4.   

Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Entities:  

Keywords:  DNA and protein interaction; Iodidoplatinum complex; cytotoxicity

Year:  2010        PMID： 24900222      PMCID： PMC4007831          DOI： 10.1021/ml100081e

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  26 in total

Review 1.  Current status of the development of trans-platinum antitumor drugs.

Authors:  J M Pérez; M A Fuertes; C Alonso; C Navarro-Ranninger
Journal:  Crit Rev Oncol Hematol       Date:  2000-08       Impact factor: 6.312

Review 2.  Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies.

Authors:  Angela Casini; Annalisa Guerri; Chiara Gabbiani; Luigi Messori
Journal:  J Inorg Biochem       Date:  2008-01-08       Impact factor: 4.155

3.  Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound.

Authors:  Angela Casini; Chiara Gabbiani; Elena Michelucci; Giuseppe Pieraccini; Gloriano Moneti; Paul J Dyson; Luigi Messori
Journal:  J Biol Inorg Chem       Date:  2009-03-14       Impact factor: 3.358

4.  DNA as a possible target for antitumor ruthenium(III) complexes.

Authors:  E Gallori; C Vettori; E Alessio; F G Vilchez; R Vilaplana; P Orioli; A Casini; L Messori
Journal:  Arch Biochem Biophys       Date:  2000-04-01       Impact factor: 4.013

Review 5.  Relationships between reduction properties and cancer cell growth inhibitory activities of cis-dichloro- and cis-diiodo-Pt(IV)-ethylenediamines.

Authors:  N A Kratochwil; P J Bednarski
Journal:  Arch Pharm (Weinheim)       Date:  1999-08       Impact factor: 3.751

6.  Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions.

Authors:  Susana M O Quintal; Yun Qu; Adorácion G Quiroga; Joseph Moniodis; Helena I S Nogueira; Nicholas Farrell
Journal:  Inorg Chem       Date:  2005-07-25       Impact factor: 5.165

7.  Towards Antitumor Active trans-Platinum Compounds.

Authors:  Sheena M Aris; Nicholas P Farrell
Journal:  Eur J Inorg Chem       Date:  2009-04-01       Impact factor: 2.524

8.  Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles.

Authors:  Tal Peleg-Shulman; Yousef Najajreh; Dan Gibson
Journal:  J Inorg Biochem       Date:  2002-07-25       Impact factor: 4.155

9.  Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.

Authors:  Angela Casini; Chiara Gabbiani; Guido Mastrobuoni; Raffaella Zoe Pellicani; Francesco Paolo Intini; Fabio Arnesano; Giovanni Natile; Gloriano Moneti; Simona Francese; Luigi Messori
Journal:  Biochemistry       Date:  2007-10-09       Impact factor: 3.162

10.  Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug.

Authors:  L R Kelland; G Abel; M J McKeage; M Jones; P M Goddard; M Valenti; B A Murrer; K R Harrap
Journal:  Cancer Res       Date:  1993-06-01       Impact factor: 12.701
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  5 in total

1.  High in Vitro and in Vivo Tumor-Selective Novel Ruthenium(II) Complexes with 3-(2'-Benzimidazolyl)-7-fluoro-coumarin.

Authors:  Qi-Pin Qin; Zhen-Feng Wang; Xiao-Ling Huang; Ming-Xiong Tan; Bei-Bei Shi; Hong Liang
Journal:  ACS Med Chem Lett       Date:  2019-05-22       Impact factor: 4.345

2.  Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity in Vitro and in Vivo.

Authors:  Yan Yang; Yi-Dong Bin; Qi-Pin Qin; Xu-Jian Luo; Bi-Qun Zou; Hua-Xin Zhang
Journal:  ACS Med Chem Lett       Date:  2019-11-06       Impact factor: 4.345

3.  Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds.

Authors:  Caroline Bartel; Anna K Bytzek; Yulia Yu Scaffidi-Domianello; Gerlinde Grabmann; Michael A Jakupec; Christian G Hartinger; Markus Galanski; Bernhard K Keppler
Journal:  J Biol Inorg Chem       Date:  2012-01-07       Impact factor: 3.862

4.  Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes.

Authors:  Pavel Štarha; Ján Vančo; Zdeněk Trávníček; Jan Hošek; Jarmila Klusáková; Zdeněk Dvořák
Journal:  PLoS One       Date:  2016-12-01       Impact factor: 3.240

5.  New Findings in the Signaling Pathways of cis and trans Platinum Iodido Complexes' Interaction with DNA of Cancer Cells.

Authors:  Adoración G Quiroga; Marta Cama; Natalia Pajuelo-Lozano; Amparo Álvarez-Valdés; Isabel Sanchez Perez
Journal:  ACS Omega       Date:  2019-12-03
  5 in total

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