Literature DB >> 24900179

Vorinostat-like molecules as structural, stereochemical, and pharmacological tools.

Stephen Hanessian1, Luciana Auzzas2, Andreas Larsson3, Jianbin Zhang1, Giuseppe Giannini4, Grazia Gallo4, Andrea Ciacci4, Walter Cabri4.   

Abstract

The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies were performed, which positioned this compound as a potential candidate for further preclinical studies and delineated measures for improving its pharmacokinetic profile.

Entities:  

Keywords:  HDAC promiscuous inhibitors; HDAC1−11 profile; SAHA analogues; absorption and metabolism; class IIa-specific profile

Year:  2010        PMID： 24900179      PMCID： PMC4007911          DOI： 10.1021/ml100028g

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  27 in total

1.  Automated analysis of interatomic contacts in proteins.

Authors:  V Sobolev; A Sorokine; J Prilusky; E E Abola; M Edelman
Journal:  Bioinformatics       Date:  1999-04       Impact factor: 6.937

Review 2.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

Authors:  Saverio Minucci; Pier Giuseppe Pelicci
Journal:  Nat Rev Cancer       Date:  2006-01       Impact factor: 60.716

Review 3.  Histone deacetylase inhibitors: from bench to clinic.

Authors:  Marielle Paris; Marina Porcelloni; Monica Binaschi; Daniela Fattori
Journal:  J Med Chem       Date:  2008-02-05       Impact factor: 7.446

4.  The use of diversity profiling to characterize chemical modulators of the histone deacetylases.

Authors:  Leonard Blackwell; Jacqueline Norris; Carla M Suto; William P Janzen
Journal:  Life Sci       Date:  2008-03-21       Impact factor: 5.037

Review 5.  Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.

Authors:  Paul A Marks; Ronald Breslow
Journal:  Nat Biotechnol       Date:  2007-01       Impact factor: 54.908

6.  In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors.

Authors:  Roula Konsoula; Mira Jung
Journal:  Int J Pharm       Date:  2008-05-13       Impact factor: 5.875

7.  Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.

Authors:  Christian A Olsen; M Reza Ghadiri
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446

8.  Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

Authors:  Stephen Hanessian; Luciana Auzzas; Giuseppe Giannini; Mauro Marzi; Walter Cabri; Marcella Barbarino; Loredana Vesci; Claudio Pisano
Journal:  Bioorg Med Chem Lett       Date:  2007-09-08       Impact factor: 2.823

9.  Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line.

Authors:  M C Grès; B Julian; M Bourrié; V Meunier; C Roques; M Berger; X Boulenc; Y Berger; G Fabre
Journal:  Pharm Res       Date:  1998-05       Impact factor: 4.200

10.  Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.

Authors:  Albert A Bowers; Thomas J Greshock; Nathan West; Guillermina Estiu; Stuart L Schreiber; Olaf Wiest; Robert M Williams; James E Bradner
Journal:  J Am Chem Soc       Date:  2009-03-04       Impact factor: 15.419
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  2 in total

Review 1.  An Insight into the Medicinal Chemistry Perspective of Macrocyclic Derivatives with Antitumor Activity: A Systematic Review.

Authors:  Yan Liang; Ru Fang; Qiu Rao
Journal:  Molecules       Date:  2022-04-29       Impact factor: 4.927

2.  In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.

Authors:  Jean-Baptiste Garsi; Lorenzo Sernissi; Vito Vece; Stephen Hanessian; Alison N McCracken; Grigor Simitian; Aimee L Edinger
Journal:  Eur J Med Chem       Date:  2018-09-21       Impact factor: 6.514
  2 in total

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