| Literature DB >> 17892933 |
Stephen Hanessian1, Luciana Auzzas, Giuseppe Giannini, Mauro Marzi, Walter Cabri, Marcella Barbarino, Loredana Vesci, Claudio Pisano.
Abstract
A series of omega-alkoxy ethers were prepared with variation of the length of the aliphatic chain of suberoylanilide hydroxamic acid (SAHA, vorinostat). Eight carbon long chain analogues showed the best activity, among which several substituted benzyl ether derivatives exhibited inhibitory activity on HDAC comparable to SAHA, and antiproliferative activity on three human cell lines (NB4, H460, and HCT-116) better than SAHA. However, no significant difference in antiproliferative activity was observed between two enantiomers bearing the benzyl ether moiety.Entities:
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Year: 2007 PMID： 17892933 DOI： 10.1016/j.bmcl.2007.09.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823