Literature DB >> 24900048

Giant Cell Tumor Pulmonary Metastases Mimic Primary Malignant Pulmonary Nodules on (18)F-FDG PET/CT.

William Makis1, Yazan Z Alabed2, Ayoub Nahal3, Javier A Novales-Diaz2, Marc Hickeson2.   

Abstract

A 59-year-old man with a 30-year history of multiple recurrences of a giant cell tumor (GCT) of the left knee was referred for an (18)F-FDG PET/CT to evaluate a solitary pulmonary nodule. The nodule was mildly FDG-avid, raising suspicion of malignancy. It was excised and histologically proven to be a GCT pulmonary metastasis. A follow-up PET/CT done 2 years later revealed a new, larger lung mass that was more intensely FDG-avid, but of the same histology. This rare report highlights a pitfall in the evaluation of solitary pulmonary lesions by (18)F-FDG PET/CT in patients with GCT of the bone.

Entities:  

Keywords:  FDG; GCT; Giant cell tumor; PET/CT; Pulmonary metastases

Year:  2012        PMID： 24900048      PMCID： PMC4042995          DOI： 10.1007/s13139-012-0134-z

Source DB:  PubMed          Journal:  Nucl Med Mol Imaging        ISSN： 1869-3474


  13 in total

Review 1.  Giant cell tumor of bone.

Authors:  Robert E Turcotte
Journal:  Orthop Clin North Am       Date:  2006-01       Impact factor: 2.472

Review 2.  Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation.

Authors:  A M McKinney; P Reichert; J Short; T Dhurairaj; K SantaCruz; Z McKinney; S Kieffer
Journal:  AJNR Am J Neuroradiol       Date:  2006 Nov-Dec       Impact factor: 3.825

3.  Spindle cell sarcoma degeneration of giant cell tumor of the knee, imaged with F-18 FDG PET-CT and Tc-99m MDP bone scan.

Authors:  William Makis; Marc Hickeson
Journal:  Clin Nucl Med       Date:  2010-02       Impact factor: 7.794

4.  FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions.

Authors:  J Aoki; H Watanabe; T Shinozaki; K Takagishi; H Ishijima; N Oya; N Sato; T Inoue; K Endo
Journal:  Radiology       Date:  2001-06       Impact factor: 11.105

5.  Use of a corrected standardized uptake value based on the lesion size on CT permits accurate characterization of lung nodules on FDG-PET.

Authors:  Marc Hickeson; Mijin Yun; Alexander Matthies; Hongming Zhuang; Lars-Eric Adam; Lester Lacorte; Abass Alavi
Journal:  Eur J Nucl Med Mol Imaging       Date:  2002-10-02       Impact factor: 9.236

6.  The role of quantitative (18)F-FDG PET studies for the differentiation of malignant and benign bone lesions.

Authors:  Antonia Dimitrakopoulou-Strauss; Ludwig G Strauss; Thomas Heichel; Hua Wu; Cyrill Burger; Ludger Bernd; Volker Ewerbeck
Journal:  J Nucl Med       Date:  2002-04       Impact factor: 10.057

7.  Grading of tumors and tumorlike lesions of bone: evaluation by FDG PET.

Authors:  M Schulte; D Brecht-Krauss; B Heymer; A Guhlmann; E Hartwig; M R Sarkar; C G Diederichs; A Von Baer; J Kotzerke; S N Reske
Journal:  J Nucl Med       Date:  2000-10       Impact factor: 10.057

8.  Metastases from histologically benign giant-cell tumor of bone.

Authors:  M G Rock; D J Pritchard; K K Unni
Journal:  J Bone Joint Surg Am       Date:  1984-02       Impact factor: 5.284

9.  18F-FDG kinetics and gene expression in giant cell tumors.

Authors:  Ludwig G Strauss; Antonia Dimitrakopoulou-Strauss; Dirk Koczan; Ludger Bernd; Uwe Haberkorn; Volker Ewerbeck; Hans-Jürgen Thiesen
Journal:  J Nucl Med       Date:  2004-09       Impact factor: 10.057

10.  Accuracy of PET for diagnosis of solid pulmonary lesions with 18F-FDG uptake below the standardized uptake value of 2.5.

Authors:  Yaichiro Hashimoto; Tetsuya Tsujikawa; Chisato Kondo; Masako Maki; Mitsuru Momose; Atsushi Nagai; Takamasa Ohnuki; Toshio Nishikawa; Kiyoko Kusakabe
Journal:  J Nucl Med       Date:  2006-03       Impact factor: 10.057
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