PURPOSE/AIM: Past work shows an inconsistent relationship between dairy intake and cognition in healthy older adults. A cross-sectional design was conducted to examine dairy consumption, cognitive dysfunction, and cerebral blood flow in a sample of older adults with heart failure (HF) to clarify their association in this population at high risk for adverse neurocognitive outcomes. MATERIALS AND METHODS: A total of 86 older adults with HF (70.39 ± 9.51 years; 33.1% female) underwent neuropsychological testing, transcranial Doppler (TCD) sonography to quantify cerebral blood flow. Dairy intake was quantified using a brief self-report questionnaire. RESULTS: Partial correlations between the dairy consumption questionnaire and neuropsychological tests were conducted adjusting for HF severity, age, and sex. Contrary to expectations, results showed greater dairy intake was associated with poorer memory (r = -0.21, p = 0.01) and higher pulsatility index in the medial cerebral artery (r = -0.17, p = 0.05). CONCLUSION: Results suggest that greater dairy intake was associated with poorer memory performance in older adults with HF. Several possible explanations for these findings exist, including the contribution of high-fat dairy to underlying physiological processes that promote vascular cognitive impairment. Prospective studies employing objective measures specific to high and low fat dairy are needed to clarify this possibility.
PURPOSE/AIM: Past work shows an inconsistent relationship between dairy intake and cognition in healthy older adults. A cross-sectional design was conducted to examine dairy consumption, cognitive dysfunction, and cerebral blood flow in a sample of older adults with heart failure (HF) to clarify their association in this population at high risk for adverse neurocognitive outcomes. MATERIALS AND METHODS: A total of 86 older adults with HF (70.39 ± 9.51 years; 33.1% female) underwent neuropsychological testing, transcranial Doppler (TCD) sonography to quantify cerebral blood flow. Dairy intake was quantified using a brief self-report questionnaire. RESULTS: Partial correlations between the dairy consumption questionnaire and neuropsychological tests were conducted adjusting for HF severity, age, and sex. Contrary to expectations, results showed greater dairy intake was associated with poorer memory (r = -0.21, p = 0.01) and higher pulsatility index in the medial cerebral artery (r = -0.17, p = 0.05). CONCLUSION: Results suggest that greater dairy intake was associated with poorer memory performance in older adults with HF. Several possible explanations for these findings exist, including the contribution of high-fat dairy to underlying physiological processes that promote vascular cognitive impairment. Prospective studies employing objective measures specific to high and low fat dairy are needed to clarify this possibility.
Authors: Alexandra T Wade; Courtney R Davis; Kathryn A Dyer; Jonathan M Hodgson; Richard J Woodman; Hannah A D Keage; Karen J Murphy Journal: Nutrients Date: 2017-02-16 Impact factor: 5.717