Literature DB >> 24893961

A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis.

Jung Min Shin1, Seol-Hee Kim, Thavasyappan Thambi, Dong Gil You, Jueun Jeon, Jong Oh Lee, Bong Youl Chung, Dong-Gyu Jo, Jae Hyung Park.   

Abstract

In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

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Year:  2014        PMID： 24893961     DOI： 10.1039/c4cc02595d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  Trojan horses and guided missiles: targeted therapies in the war on arthritis.

Authors:  Mathieu Ferrari; Shimobi C Onuoha; Costantino Pitzalis
Journal:  Nat Rev Rheumatol       Date:  2015-03-03       Impact factor: 20.543

Review 2.  Polysaccharide-based nanoparticles for theranostic nanomedicine.

Authors:  M Swierczewska; H S Han; K Kim; J H Park; S Lee
Journal:  Adv Drug Deliv Rev       Date:  2015-11-27       Impact factor: 15.470

3.  Hyaluronan-Based Nanohydrogels as Effective Carriers for Transdermal Delivery of Lipophilic Agents: Towards Transdermal Drug Administration in Neurological Disorders.

Authors:  Seong Uk Son; Jae-Woo Lim; Taejoon Kang; Juyeon Jung; Eun-Kyung Lim
Journal:  Nanomaterials (Basel)       Date:  2017-12-04       Impact factor: 5.076

4.  A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy.

Authors:  Jung Min Shin; Seok Ho Song; N Vijayakameswara Rao; Eun Sook Lee; Hyewon Ko; Jae Hyung Park
Journal:  Biomater Res       Date:  2018-08-14

5.  Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy.

Authors:  Meiling Zhou; Jierong Hou; Zhirong Zhong; Na Hao; Yan Lin; Chunhong Li
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419

6.  Bone-targeted methotrexate-alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo.

Authors:  Zi'ang Xie; Guanxiong Liu; Pan Tang; Xuewu Sun; Shuai Chen; An Qin; Peizhi Zhu; Jianfeng Zhang; Shunwu Fan
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419

7.  Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis.

Authors:  Weifeng Duan; Huan Li
Journal:  J Nanobiotechnology       Date:  2018-07-30       Impact factor: 10.435

8.  Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy.

Authors:  Fei Hao; Robert J Lee; Lihuang Zhong; Shiyan Dong; Chunmiao Yang; Lirong Teng; Qingfan Meng; Jiahui Lu; Jing Xie; Lesheng Teng
Journal:  Theranostics       Date:  2019-07-09       Impact factor: 11.556

Review 9.  Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies.

Authors:  Qin Wang; Xianyan Qin; Jiyu Fang; Xun Sun
Journal:  Acta Pharm Sin B       Date:  2021-03-12       Impact factor: 11.413

10.  Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels.

Authors:  Jinyu Wang; Weibo Zhao; Haixiao Chen; An Qin; Peizhi Zhu
Journal:  Nanoscale Res Lett       Date:  2017-10-24       Impact factor: 4.703
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