Slip Reduction Rate between Minimal Invasive and Conventional Unilateral Transforaminal Interbody Fusion in Patients with Low-Grade Isthmic Spondylolisthesis.

OBJECTIVE: To compare the slip reduction rate and clinical outcomes between unilateral conventional transforaminal lumbar interbody fusion (conventional TLIF) and unilateral minimal invasive TLIF (minimal TLIF) with pedicle screw fixation for treatment of one level low-grade symptomatic isthmic spondylolisthesis.
METHODS: Between February 2008 and April 2012, 25 patients with low-grade isthmic spondylolisthesis underwent conventional TLIF (12 patients) and minimal TLIF (13 patients) in single university hospital by a single surgeon. Lateral radiographs of lumbar spine were taken 12 months after surgery to analyze the degree of slip reduction and the clinical outcome. All measurements were performed by a single observer.
RESULTS: The demographic data between conventional TLIF and minimal TLIF were not different. Slip percentage was reduced from 15.00% to 8.33% in conventional TLIF, and from 14.15% to 9.62% in minimal TLIF. In both groups, slip percentage was significantly improved postoperatively (p=0.002), but no significant intergroup differences of slip percentage in preoperative and postoperative were found. The reduction rate also not different between conventional TLIF (45.41±28.80%) and minimal TLIF (32.91±32.12%, p=0.318).
CONCLUSION: Conventional TLIF and minimal TLIF with pedicle screw fixation showed good slip reduction in patients with one level low-grade symptomatic isthmic spondylolisthesis. The slip percentage and reduction rate were similar in the conventional TLIF and minimal TLIF.

INTRODUCTION

Spondylolisthesis is an unstable lumbar disease demonstrated in approximately 6% of the general population and occurs most often at L4-L5 and L5-S1 levels10,13,14). Anatomy research indicates that isthmic spondylolisthesis usually occurs within the scope of 2 to 9mm beneath the pedicles, resulting in the defects in bony contacts in the pars interarticularis to form pseudarthrosis, the gap of which is filled with fibrous connective tissue and chondroid tissue, which we called pars interarticularis scar3). Symptomatic patients with isthmic spondylolisthesis usually require surgical intervention, the goals of which include the stabilization of the motion segment, the decompression of neural elements, the reconstitution of disc space height, and the restoration of sagittal plane translational and rotational alignment6). Minimally invasive transforaminal lumbar interbody fusion (TLIF) is a relatively novel spinal fusion technique which was developed in recent years on the basis of conventional TLIF3). But, little is known about the slip reduction according to the unilateral TLIF methods. This study was to compare the slip reduction rate and clinical outcome between unilateral conventional TLIF (conventional TLIF) with pedicle screw fixation and unilateral minimal invasive TLIF (minimal TLIF) with pedicle screw fixation for treatment of one level low-grade symptomatic isthmic spondylolisthesis.

MATERIALS AND METHODS

1. Clinical material

Transforaminal lumbar interbody fusion is a relatively new technique of lumbar arthrodesis via posterior transforaminal approach to the disc, indicated mainly in cases of degenerative disc disease, low grade spondylolisthesis and reoperation for disc herniation, especially when there is indication for interbody fusion and posterior decompression. The main advantage of TLIF is that it allows the complete removal of the intervertebral disc through the vertebral foramen, decompression of the spinal canal and vertebral foramen with minimum risk of neural lesion, due to the access being lateral to the nerve roots. Between February 2008 and April 2012, 25 patients with low-grade isthmic spondylolisthesis underwent conventional TLIF (12 patients) and minimal TLIF (13 patients) in single university hospital by a single surgeon were included in the study-including 6 males and 19 females, whose average age was 51.96 years (21-72 years). All of them had preoperative radiographs, computed tomography scans, as well as magnetic resonance imaging, and all surgical procedures were performed by a single surgeon (SHY).

2. Assessment of slip reduction and clinical results

Lateral radiographs of lumbar spine were taken 12 months after surgery to analyze the degree of reduction. All measurements were performed by a single observer and were expressed as means±standard deviations. To control for small variations, the radiographic results were represented in percentage. Slip percentage was measured as a percentage of distance from the posterior border of the caudal to the posterior border of the rostral vertebra, normalized to the superior endplate diameter of the former as it presented in Fig. 115). Clinical outcome was measured by visual analog scale (VAS; score range: 0 to 10, with 0 reflecting no pain).

Fig. 1

Slip percentage measured by a percentage of distance from the posterior border of the caudal to the posterior border of the rostral vertebra: slip percentage was decreased from 26.7% to 17.9% in conventional TLIF (A and B) and was decreased from 27.6% to 21.8% in minimal TLIF (C and D)

3. Surgical technique of minimal TLIF

Fluoroscopy was used to determine the operative level in minimal TLIF technique. The minimal TLIF procedure was performed on the side of radicular symptoms. If both the legs were symptomatic, the approach was from the side of more severe pathology and contralateral lamina and foramina decompressed by a unilateral exposure. An incision was made 3 to 4 cm off midline. Sequential soft tissue dilators were inserted through the incision down to the facet complex until the desired working diameter was achieved. A facetectomy was then performed using a high-speed drill from lateral to medial side to expose the posterolateral aspect of the disc. Intradiscal distraction and disc space preparation were done using standard interbody fusion instruments. Cartilaginous material was removed from the endplates using the endplate scraper. An interbody graft was then placed in a direction anterior and contralateral to the annulotomy within the interbody space. Autograft was not used in any cases. Fluoroscopy was used to ensure satisfactory placement of the graft. When necessary, the contralateral ligamentumflavum was resected to expose the contralateral exiting and traversing nerve roots. If needed, the tubular retractor was angled contralaterally so that a more extensive boney decompression could be done. The tubular retractor was then removed and percutaneous pedical screws placed immediately above and below the interbody segment to be fused. Under fluoroscopic guidance, a Jamshidi needle was inserted into the pedicles. A K-wire was then passed through the Jamshidi trocar into the pedicles. Using cannulated instruments, a bone tap followed by cannulated screw was advanced over the K-wire. The rod was then placed percutaneously to connect the screws. Compression was applied to the construct before final tightening, providing compression of the bone graft and maximizing lordosis. All wounds were copiously irrigated and the wounds were closed in layers.

4. Surgical technique of conventional TLIF

A midline skin incision was used in conventional TLIF. The fascia was incised and the paravertebral muscles were dissected from the spine. Radiographs were used to check the appropriate level. Bilateral pedicle screw rod constructs were inserted and laminectomy and unilateral facetectomy was then performed at that level. This was followed by unilateral anulotomy, discectomy, and placement of the interbody graft. Similar to the minimal TLIF approach, cartilaginous material was removed from the endplates using the endplate scraper. Interbody graft was then placed anteriorly and contralateral to the annulotomy within the interbody space. For posteriorlateral arthodesis, local autogenous bone with or without bone extenders was used for bone grafting. The wound was copiously irrigated and closed in layers.

5. Statistical analysis

SPSS software for Windows (SPSS Inc., Chicago, IL, USA) was used throughout, and statistical significance was accepted for p values of <0.050. Data were analyzed using the student, student paired t-test, and chi-square test.

RESULTS

The demographic data between conventional and minimal TLIF were not different (Table 1). All the cases were followed up more than 12 months. Slip percentage was reduced from 15.00±6.66% to 8.33±5.31% in conventional TLIF, and from 14.15±3.76% to 9.62±5.42% in minimal TLIF (Table 2). In both groups, slip percentage was significantly improved postoperatively (p=0.002), but no significant intergroup differences of slip percentage in preoperative and postoperative were found (Table 3). The reduction rate also not different between conventional (45.41±28.80%) and minimal TLIF (32.91±32.12%, p=0.318). No neurologic complications were encountered. There were no signs of instrumentation failure and no visible subsidence of the cages until 12 months follow-up periods. All patients had their symptoms significantly improved, and the VAS decreased from 7.00±2.69 before operation to 3.11±1.86 at 12 months after operation in conventional TLIF, and from 7.14±3.15 before operation to 3.52±2.24 at 12 months after operation in minimal TLIF (Table 3). The clinical outcome was not correlated with reduction rate (p=0.341).

Table 1

Demographic date between convention and minimal TLIF with pedicle screw fixation

TLIF, transforaminal lumbar interbody fusion; conventional TLIF, unilateral conventional TLIF with pedicle screw fixation; minimal TLIF, unilateral minimal invasive TLIF with pedicle screw fixation.

Table 2

Comparison result of preoperative and postoperative slip grade

conventional TLIF, unilateral conventional transforaminal lumbar interbody fusion with pedicle screw fixation; minimal TLIF, unilateral minimal invasive transforaminal lumbar interbody fusion with pedicle screw fixation

Table 3

Preoperative and postoperative clinical and radiologic result

conventional TLIF, unilateral conventional transforaminal lumbar interbody fusion with pedicle screw fixation; minimal TLIF, unilateral minimal invasive transforaminal lumbar interbody fusion with pedicle screw fixation; VAS, visual analog scale.

DISCUSSION

The advent of minimally invasive surgery had provided surgeons new techniques for treating clinical disease7). Minimally invasive spine surgery aims to reduce approach related morbidity, while producing clinical outcomes comparable to its open predecessors7). One important example of this is the development of minimally invasive techniques for lumbar inter-body fusion, including TLIF2,7). The minimal invasive TLIF technique, has displayed comparable outcomes to conventional TLIF, while adding the benefits of less approach related morbidity, decreased intraoperative blood loss, and shorter hospital stays9,11). However, critics of the technique have noted that the minimal TLIF has longer operative times and exposes patients to increased fluoroscopic radiation. Over the past decade minimal TLIF has been shown to have a number of benefits, especially with regard to perioperative outcomes. However, it may have its own unique challenges and potential morbidity. Ultimately, comparing the known literature of a conventional TLIF approach to published reports on minimal TLIF will identify the unique risks and benefits associated with each.

Generally, clinical result between conventional and minimal TLIF were reported the similar or superior result in minimal invasive technique4,5,17). All preoperative parameters except the operation time were superior in minimal TLIF than the conventional TLIF4,5,17,18,20). Most article were concluded to similar the overall complication rate in two methods2,4,5,7,12,20). But, all authors reported that radiation hazard is less effective in minimal TLIF, and concluded the main disadvantage of minimal TLIF4,5,17). In radiological study, although many reported using the different criteria about the bone fusion, but all reported studies concluded the fusion rate between two TLIF technique is similar17,18). But, the comparisonal data slip reduction in patients with low-grade spondylolisthesis is lack of data, yet. In this study, the authors compared the slip reduction rate between two different unilateral TLIF with pedicle screw fixation for treatment of one level low-grade symptomatic isthmic spondylolisthesis. To best knowledge to authors, this comparison is not published in literature yet, although the size of data was not sufficient to show the conclusive statistical evidence.

In this small case series about 25 patients with low-grade isthmic spondylolisthesis underwent conventional TLIF or minimal TLIF showed, the slip percentage was significantly improved postoperatively in both TLIF techniques (p=0.002). All patients had their symptoms significantly improved after operation in both groups. But, the slip percentage in pre/postoperative periods and reduction rate after operation also not different between conventional and minimal TLIF. The similar results were also observed in the literatures, but most of them are focused only conventional or minimal TLIF. Recniket al.8) reported that significantly decreased translational slip from 20.7% to 14.9% after conventional TLIF in 32 patients with single-level isthmic spondylolisthesis (p<0.001). Yan et al.16) also reported the slip was reduced from 31.4±8.3 to 8.2±2.6%, and the average of reduction rate was 75.4±6.2 in conventional TLIF. In minimal invasive techniques, Pan et al.3) reported decreased translational slip from 24.2% to 10.5% after operation, and Tsahtsarlis et al.19) also reported the anatomical reduction of the spondylolisthesis was complete in 16 patients (69.6%) and incomplete in seven (30.3%). This result was similar to this data, but direct comparisonal result is observed in only this presented study. Some authors reported surgical technique to increase the reduction rate among spondylolisthesis, the key technique is circumferential disc or ligament reconstruction which prevent the reduction1). A bilateral traversing and exiting nerve roots decompression is a safer option prior to performing the deformity reduction and fixation, and the proposed minimally invasive technique may help in reducing surgical morbidity and improving postoperative recovery.

The conventional and minimal TLIF showed excellent slip reduction in patients with one level low-grade symptomatic isthmic spondylolisthesis and slip percentage and reduction rate were similar in the conventional and minimal TLIF as we presented. But, as we commented, this study is small case series about 25 patients, so the statistical analysis had an opportunity into the trap of the type I error. Indeed, we could not access the other meaningful clinical outcomes such as Oswestrydisability index (ODI), neurogenic symptom score (NSS) andshort form 36 (SF-36) because of using retrograde data review. In the statistical analysis with tripling of this data showed statistical difference of reduction rate (p=0.018), so well-designed longitudinal prospective study with a larger number of isthmic spondylolisthesis could presented the different reductional result between conventional and minimal TLIF.

CONCLUSION

The conventional and minimal TLIF with pedicle screw fixation showed excellent slip reduction in patients with one level low-grade symptomatic isthmic spondylolisthesis. The slip percentage and reduction rate were similar in the conventional and minimal TLIF.