Literature DB >> 24890588

OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain.

Rodrigo Cayô1, María Merino2, Belén Ruiz Del Castillo3, María Eliecer Cano3, Jorge Calvo3, Germán Bou2, Luis Martínez-Martínez4.   

Abstract

A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID: 24890588      PMCID: PMC4136014          DOI: 10.1128/AAC.02633-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  24 in total

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2.  Production of a plasmid-encoded OXA-72 β-lactamase associated with resistance to carbapenems in a clinical isolate Acinetobacter junii.

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3.  Outbreak of Acinetobacter genomic species 3 in a Dutch intensive care unit.

Authors:  D Idzenga; M A Schouten; A R H van Zanten
Journal:  J Hosp Infect       Date:  2006-08       Impact factor: 3.926

4.  Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis.

Authors:  Rodrigo E Mendes; Katia A Kiyota; Jussimara Monteiro; Mariana Castanheira; Soraya S Andrade; Ana C Gales; Antonio C C Pignatari; Sergio Tufik
Journal:  J Clin Microbiol       Date:  2006-11-08       Impact factor: 5.948

Review 5.  Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.

Authors:  L Poirel; P Nordmann
Journal:  Clin Microbiol Infect       Date:  2006-09       Impact factor: 8.067

6.  Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.

Authors:  Neil Woodford; Matthew J Ellington; Juliana M Coelho; Jane F Turton; M Elaina Ward; Susan Brown; Sebastian G B Amyes; David M Livermore
Journal:  Int J Antimicrob Agents       Date:  2006-03-24       Impact factor: 5.283

7.  OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.

Authors:  G Bou; A Oliver; J Martínez-Beltrán
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8.  Identification of Acinetobacter genomic species by amplified ribosomal DNA restriction analysis.

Authors:  M Vaneechoutte; L Dijkshoorn; I Tjernberg; A Elaichouni; P de Vos; G Claeys; G Verschraegen
Journal:  J Clin Microbiol       Date:  1995-01       Impact factor: 5.948

9.  Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.

Authors:  Claire Héritier; Laurent Poirel; Daniel Aubert; Patrice Nordmann
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6.  Molecular Epidemiology of Emerging Carbapenem Resistance in Acinetobacter nosocomialis and Acinetobacter pittii in Taiwan, 2010 to 2014.

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Journal:  mBio       Date:  2022-03-21       Impact factor: 7.786

8.  Molecular Epidemiology of Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Isolated From Children at the Hospital Infantil de México Federico Gómez.

Authors:  Jetsi Mancilla-Rojano; Sara A Ochoa; Juan Pablo Reyes-Grajeda; Víctor Flores; Oscar Medina-Contreras; Karina Espinosa-Mazariego; Israel Parra-Ortega; Daniela De La Rosa-Zamboni; María Del Carmen Castellanos-Cruz; José Arellano-Galindo; Miguel A Cevallos; Rigoberto Hernández-Castro; Juan Xicohtencatl-Cortes; Ariadnna Cruz-Córdova
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  8 in total

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