| Literature DB >> 24890588 |
Rodrigo Cayô1, María Merino2, Belén Ruiz Del Castillo3, María Eliecer Cano3, Jorge Calvo3, Germán Bou2, Luis Martínez-Martínez4.
Abstract
A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.Entities:
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Year: 2014 PMID: 24890588 PMCID: PMC4136014 DOI: 10.1128/AAC.02633-13
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191