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Literature DB >> 24883009

After disappointments, Alzheimer's researchers seek out new paths: biomarkers and combination therapies may lead to disease-modifying treatments, experts say.

Abstract

Developing a disease-modifying treatment for Alzheimer's disease has stymied researchers. A collaborative re-examination of premises that guided disappointing earlier trials is under way, with talk of new targets and combination therapies.

Entities: Disease

Year: 2014 PMID： 24883009 PMCID： PMC4029120

Source DB: PubMed Journal: P T ISSN： 1052-1372

20 in total

1. Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.

Authors: Steven E Arnold; Natalia Louneva; Kajia Cao; Li-San Wang; Li-Ying Han; David A Wolk; Selamawit Negash; Sue E Leurgans; Julie A Schneider; Aron S Buchman; Robert S Wilson; David A Bennett
Journal: Neurobiol Aging Date: 2012-05-02 Impact factor: 4.673

2. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease.

Authors: Chun-Fang Xia; Janna Arteaga; Gang Chen; Umesh Gangadharmath; Luis F Gomez; Dhanalakshmi Kasi; Chung Lam; Qianwa Liang; Changhui Liu; Vani P Mocharla; Fanrong Mu; Anjana Sinha; Helen Su; A Katrin Szardenings; Joseph C Walsh; Eric Wang; Chul Yu; Wei Zhang; Tieming Zhao; Hartmuth C Kolb
Journal: Alzheimers Dement Date: 2013-02-12 Impact factor: 21.566

3. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.

Authors: Rachelle S Doody; Ronald G Thomas; Martin Farlow; Takeshi Iwatsubo; Bruno Vellas; Steven Joffe; Karl Kieburtz; Rema Raman; Xiaoying Sun; Paul S Aisen; Eric Siemers; Hong Liu-Seifert; Richard Mohs
Journal: N Engl J Med Date: 2014-01-23 Impact factor: 91.245

4. Plasma phospholipids identify antecedent memory impairment in older adults.

Authors: Mark Mapstone; Amrita K Cheema; Massimo S Fiandaca; Xiaogang Zhong; Timothy R Mhyre; Linda H MacArthur; William J Hall; Susan G Fisher; Derick R Peterson; James M Haley; Michael D Nazar; Steven A Rich; Dan J Berlau; Carrie B Peltz; Ming T Tan; Claudia H Kawas; Howard J Federoff
Journal: Nat Med Date: 2014-03-09 Impact factor: 53.440

5. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.

Authors: Victor L Villemagne; Samantha Burnham; Pierrick Bourgeat; Belinda Brown; Kathryn A Ellis; Olivier Salvado; Cassandra Szoeke; S Lance Macaulay; Ralph Martins; Paul Maruff; David Ames; Christopher C Rowe; Colin L Masters
Journal: Lancet Neurol Date: 2013-03-08 Impact factor: 44.182

6. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.

Authors: William E Klunk; Henry Engler; Agneta Nordberg; Yanming Wang; Gunnar Blomqvist; Daniel P Holt; Mats Bergström; Irina Savitcheva; Guo-feng Huang; Sergio Estrada; Birgitta Ausén; Manik L Debnath; Julien Barletta; Julie C Price; Johan Sandell; Brian J Lopresti; Anders Wall; Pernilla Koivisto; Gunnar Antoni; Chester A Mathis; Bengt Långström
Journal: Ann Neurol Date: 2004-03 Impact factor: 10.422

7. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study.

Authors: Eric M Reiman; Yakeel T Quiroz; Adam S Fleisher; Kewei Chen; Carlos Velez-Pardo; Marlene Jimenez-Del-Rio; Anne M Fagan; Aarti R Shah; Sergio Alvarez; Andrés Arbelaez; Margarita Giraldo; Natalia Acosta-Baena; Reisa A Sperling; Brad Dickerson; Chantal E Stern; Victoria Tirado; Claudia Munoz; Rebecca A Reiman; Matthew J Huentelman; Gene E Alexander; Jessica B S Langbaum; Kenneth S Kosik; Pierre N Tariot; Francisco Lopera
Journal: Lancet Neurol Date: 2012-11-06 Impact factor: 44.182

8. Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders.

Authors: Bruno Vellas; R Black; Leon J Thal; Nick C Fox; M Daniels; G McLennan; C Tompkins; C Leibman; M Pomfret; Michael Grundman
Journal: Curr Alzheimer Res Date: 2009-04 Impact factor: 3.498

Review 9. Developing novel blood-based biomarkers for Alzheimer's disease.

Authors: Heather M Snyder; Maria C Carrillo; Francine Grodstein; Kim Henriksen; Andreas Jeromin; Simon Lovestone; Michelle M Mielke; Sid O'Bryant; Manual Sarasa; Magnus Sjøgren; Holly Soares; Jessica Teeling; Eugenia Trushina; Malcolm Ward; Tim West; Lisa J Bain; Diana W Shineman; Michael Weiner; Howard M Fillit
Journal: Alzheimers Dement Date: 2014-01 Impact factor: 21.566

Review 10. Dominantly Inherited Alzheimer Network: facilitating research and clinical trials.

Authors: Krista L Moulder; B Joy Snider; Susan L Mills; Virginia D Buckles; Anna M Santacruz; Randall J Bateman; John C Morris
Journal: Alzheimers Res Ther Date: 2013-10-17 Impact factor: 6.982

4 in total

1. Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease.

Authors: Jon B Toledo; Maria Bjerke; Xiao Da; Susan M Landau; Norman L Foster; William Jagust; Clifford Jack; Michael Weiner; Christos Davatzikos; Leslie M Shaw; John Q Trojanowski
Journal: JAMA Neurol Date: 2015-05 Impact factor: 18.302