Literature DB >> 24365657

Developing novel blood-based biomarkers for Alzheimer's disease.

Heather M Snyder1, Maria C Carrillo2, Francine Grodstein3, Kim Henriksen4, Andreas Jeromin5, Simon Lovestone6, Michelle M Mielke7, Sid O'Bryant8, Manual Sarasa9, Magnus Sjøgren10, Holly Soares11, Jessica Teeling12, Eugenia Trushina13, Malcolm Ward14, Tim West15, Lisa J Bain16, Diana W Shineman17, Michael Weiner18, Howard M Fillit17.   

Abstract

Alzheimer's disease is the public health crisis of the 21st century. There is a clear need for a widely available, inexpensive and reliable method to diagnosis Alzheimer's disease in the earliest stages, track disease progression, and accelerate clinical development of new therapeutics. One avenue of research being explored is blood based biomarkers. In April 2012, the Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened top scientists from around the world to discuss the state of blood based biomarker development. This manuscript summarizes the meeting and the resultant discussion, including potential next steps to move this area of research forward.
Copyright © 2014. Published by Elsevier Inc.

Entities:  

Keywords:  Alzheimer's disease; Biomarker; Blood based biomarker; Diagnostics; Early detection; Early diagnosis

Mesh：

Substances：

Year:  2014        PMID： 24365657      PMCID： PMC4769619          DOI： 10.1016/j.jalz.2013.10.007

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN： 1552-5260            Impact factor:   21.566


  45 in total

1.  Evaluating the comparability of gene expression in blood and brain.

Authors:  Patrick F Sullivan; Cheng Fan; Charles M Perou
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2006-04-05       Impact factor: 3.568

2.  Plasma clusterin and the risk of Alzheimer disease.

Authors:  Elisabeth M C Schrijvers; Peter J Koudstaal; Albert Hofman; Monique M B Breteler
Journal:  JAMA       Date:  2011-04-06       Impact factor: 56.272

3.  Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease.

Authors:  Pascale Fehlbaum-Beurdeley; Olivier Sol; Laurent Désiré; Jacques Touchon; Thierry Dantoine; Martine Vercelletto; Audrey Gabelle; Anne-Charlotte Jarrige; Raphaël Haddad; Jean Christophe Lemarié; Weiyin Zhou; Harald Hampel; Richard Einstein; Bruno Vellas
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

4.  Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma.

Authors:  Esther S Oh; Michelle M Mielke; Paul B Rosenberg; Alka Jain; Neal S Fedarko; Constantine G Lyketsos; Pankaj D Mehta
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

5.  Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients.

Authors:  Christoph Laske; Michael Schmohl; Thomas Leyhe; Elke Stransky; Walter Maetzler; Daniela Berg; Andreas J Fallgatter; Thomas Joos; Janko Dietzsch
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

6.  Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia.

Authors:  G Zuliani; M Cavalieri; M Galvani; A Passaro; M R Munari; C Bosi; A Zurlo; R Fellin
Journal:  J Neurol Sci       Date:  2008-07-02       Impact factor: 3.181

7.  Systemic inflammation and disease progression in Alzheimer disease.

Authors:  C Holmes; C Cunningham; E Zotova; J Woolford; C Dean; S Kerr; D Culliford; V H Perry
Journal:  Neurology       Date:  2009-09-08       Impact factor: 9.910

8.  Several direct and calculated biomarkers from the amyloid-β pool in blood are associated with an increased likelihood of suffering from mild cognitive impairment.

Authors:  Virginia Pérez-Grijalba; Pedro Pesini; Inmaculada Monleón; Mercè Boada; Lluís Tárraga; Agustín Ruiz-Laza; Pablo Martínez-Lage; Itziar San-José; Manuel Sarasa
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

9.  Will posttranslational modifications of brain proteins provide novel serological markers for dementias?

Authors:  Y Wang; M G Sørensen; Q Zheng; C Zhang; M A Karsdal; K Henriksen
Journal:  Int J Alzheimers Dis       Date:  2012-06-21

10.  An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function.

Authors:  Kim Henriksen; Yaguo Wang; Mette G Sørensen; Natasha Barascuk; Joyce Suhy; Jan T Pedersen; Kevin L Duffin; Robert A Dean; Monika Pajak; Claus Christiansen; Qinlong Zheng; Morten A Karsdal
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240
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  62 in total

1.  The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

Authors:  E Cavedo; S Lista; Z Khachaturian; P Aisen; P Amouyel; K Herholz; C R Jack; R Sperling; J Cummings; K Blennow; S O'Bryant; G B Frisoni; A Khachaturian; M Kivipelto; W Klunk; K Broich; S Andrieu; M Thiebaut de Schotten; J-F Mangin; A A Lammertsma; K Johnson; S Teipel; A Drzezga; A Bokde; O Colliot; H Bakardjian; H Zetterberg; B Dubois; B Vellas; L S Schneider; H Hampel
Journal:  J Prev Alzheimers Dis       Date:  2014-12

Review 2.  Clinical Research on Alzheimer's Disease: Progress and Perspectives.

Authors:  Bin-Lu Sun; Wei-Wei Li; Chi Zhu; Wang-Sheng Jin; Fan Zeng; Yu-Hui Liu; Xian-Le Bu; Jie Zhu; Xiu-Qing Yao; Yan-Jiang Wang
Journal:  Neurosci Bull       Date:  2018-06-28       Impact factor: 5.203

Review 3.  Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.

Authors:  Aaron J Carman; Rennie Ferguson; Robert Cantu; R Dawn Comstock; Penny A Dacks; Steven T DeKosky; Sam Gandy; James Gilbert; Chad Gilliland; Gerard Gioia; Christopher Giza; Michael Greicius; Brian Hainline; Ronald L Hayes; James Hendrix; Barry Jordan; James Kovach; Rachel F Lane; Rebekah Mannix; Thomas Murray; Tad Seifert; Diana W Shineman; Eric Warren; Elisabeth Wilde; Huntington Willard; Howard M Fillit
Journal:  Nat Rev Neurol       Date:  2015-03-17       Impact factor: 42.937

4.  Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study.

Authors:  Vincent Chouraki; Sarah R Preis; Qiong Yang; Alexa Beiser; Shuo Li; Martin G Larson; Galit Weinstein; Thomas J Wang; Robert E Gerszten; Ramachandran S Vasan; Sudha Seshadri
Journal:  Alzheimers Dement       Date:  2017-06-08       Impact factor: 21.566

Review 5.  Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases.

Authors:  Eugene M Cilento; Lorrain Jin; Tessandra Stewart; Min Shi; Lifu Sheng; Jing Zhang
Journal:  J Neurochem       Date:  2019-01-31       Impact factor: 5.372

6.  PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease.

Authors:  H Hampel; S E O'Bryant; J I Castrillo; C Ritchie; K Rojkova; K Broich; N Benda; R Nisticò; R A Frank; B Dubois; V Escott-Price; S Lista
Journal:  J Prev Alzheimers Dis       Date:  2016-09-06

7.  Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.

Authors:  Sid E O'Bryant; Michelle M Mielke; Robert A Rissman; Simone Lista; Hugo Vanderstichele; Henrik Zetterberg; Piotr Lewczuk; Holly Posner; James Hall; Leigh Johnson; Yiu-Lian Fong; Johan Luthman; Andreas Jeromin; Richard Batrla-Utermann; Alcibiades Villarreal; Gabrielle Britton; Peter J Snyder; Kim Henriksen; Paula Grammas; Veer Gupta; Ralph Martins; Harald Hampel
Journal:  Alzheimers Dement       Date:  2016-11-18       Impact factor: 21.566

Review 8.  Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins.

Authors:  Ashley Swanson; Tovah Wolf; Alli Sitzmann; Auriel A Willette
Journal:  Behav Brain Res       Date:  2018-02-17       Impact factor: 3.332

Review 9.  Biomarkers in Alzheimer's disease analysis by mass spectrometry-based proteomics.

Authors:  Yahui Liu; Hong Qing; Yulin Deng
Journal:  Int J Mol Sci       Date:  2014-05-06       Impact factor: 5.923

10.  Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.

Authors:  Kwangsik Nho; Kelly Nudelman; Mariet Allen; Angela Hodges; Sungeun Kim; Shannon L Risacher; Liana G Apostolova; Kuang Lin; Katie Lunnon; Xue Wang; Jeremy D Burgess; Nilüfer Ertekin-Taner; Ronald C Petersen; Lisu Wang; Zhenhao Qi; Aiqing He; Isaac Neuhaus; Vishal Patel; Tatiana Foroud; Kelley M Faber; Simon Lovestone; Andrew Simmons; Michael W Weiner; Andrew J Saykin
Journal:  Alzheimers Dement       Date:  2020-08-05       Impact factor: 21.566
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