Literature DB >> 24880460

Ontogeny of early life immunity.

David J Dowling1, Ofer Levy2.   

Abstract

The human immune system comprises cellular and molecular components designed to coordinately prevent infection while avoiding potentially harmful inflammation and autoimmunity. Immunity varies with age, reflecting unique age-dependent challenges including fetal gestation, the neonatal phase, and infancy. Here, we review novel mechanistic insights into early life immunity, with an emphasis on emerging models of human immune ontogeny, which may inform age-specific translational development of novel anti-infectives, immunomodulators, and vaccines.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Toll-like receptor; dendritic cell; immune ontogeny; newborn infant; vaccines

Mesh：

Substances：

Year:  2014        PMID： 24880460      PMCID： PMC4109609          DOI： 10.1016/j.it.2014.04.007

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  173 in total

1.  Combined Toll-like receptor agonists synergistically increase production of inflammatory cytokines in human neonatal dendritic cells.

Authors:  Doreen Krumbiegel; Fred Zepp; Claudius Ullrich Meyer
Journal:  Hum Immunol       Date:  2007-08-29       Impact factor: 2.850

2.  Development of newborn and infant vaccines.

Authors:  Guzman Sanchez-Schmitz; Ofer Levy
Journal:  Sci Transl Med       Date:  2011-07-06       Impact factor: 17.956

3.  Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.

Authors:  Joanne G Lisciandro; Susan L Prescott; Marie G Nadal-Sims; Catherine J Devitt; Peter C Richmond; William Pomat; Peter M Siba; Patrick G Holt; Deborah H Strickland; Anita H J van den Biggelaar
Journal:  J Allergy Clin Immunol       Date:  2012-07-19       Impact factor: 10.793

4.  Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo.

Authors:  Jin-Ping Zhang; Yi Yang; Ofer Levy; Chao Chen
Journal:  Pediatr Res       Date:  2010-12       Impact factor: 3.756

5.  Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.

Authors:  M E Belderbos; G M van Bleek; O Levy; M O Blanken; M L Houben; L Schuijff; J L L Kimpen; L Bont
Journal:  Clin Immunol       Date:  2009-08-03       Impact factor: 3.969

6.  A neonatal mouse model of coxsackievirus A16 for vaccine evaluation.

Authors:  Qunying Mao; Yiping Wang; Rong Gao; Jie Shao; Xin Yao; Shuhui Lang; Chao Wang; Panyong Mao; Zhenglun Liang; Junzhi Wang
Journal:  J Virol       Date:  2012-09-05       Impact factor: 5.103

7.  Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal mice.

Authors:  Madhulika Jupelli; M Neal Guentzel; Patricia A Meier; Guangming Zhong; Ashlesh K Murthy; Bernard P Arulanandam
Journal:  J Immunol       Date:  2008-03-15       Impact factor: 5.422

8.  Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial.

Authors:  William S Pomat; Anita H J van den Biggelaar; Suparat Phuanukoonnon; Jacinta Francis; Peter Jacoby; Peter M Siba; Michael P Alpers; John C Reeder; Patrick G Holt; Peter C Richmond; Deborah Lehmann
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240

9.  Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Authors:  Cheng-Lung Ku; Horst von Bernuth; Capucine Picard; Shen-Ying Zhang; Huey-Hsuan Chang; Kun Yang; Maya Chrabieh; Andrew C Issekutz; Coleen K Cunningham; John Gallin; Steven M Holland; Chaim Roifman; Stephan Ehl; Joanne Smart; Mimi Tang; Franck J Barrat; Ofer Levy; Douglas McDonald; Noorbibi K Day-Good; Richard Miller; Hidetoshi Takada; Toshiro Hara; Sami Al-Hajjar; Abdulaziz Al-Ghonaium; David Speert; Damien Sanlaville; Xiaoxia Li; Frédéric Geissmann; Eric Vivier; László Maródi; Ben-Zion Garty; Helen Chapel; Carlos Rodriguez-Gallego; Xavier Bossuyt; Laurent Abel; Anne Puel; Jean-Laurent Casanova
Journal:  J Exp Med       Date:  2007-09-24       Impact factor: 14.307

10.  Pneumococcal polysaccharide abrogates conjugate-induced germinal center reaction and depletes antibody secreting cell pool, causing hyporesponsiveness.

Authors:  Stefania P Bjarnarson; Hreinn Benonisson; Giuseppe Del Giudice; Ingileif Jonsdottir
Journal:  PLoS One       Date:  2013-09-12       Impact factor: 3.240
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  141 in total

Review 1.  Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox.

Authors:  David J Dowling; Ofer Levy
Journal:  Pediatr Infect Dis J       Date:  2015-12       Impact factor: 2.129

2.  Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis.

Authors:  Ravi S Misra; Soumyaroop Bhattacharya; Heidie L Huyck; Jyh-Chiang E Wang; Christopher G Slaunwhite; Sharleen L Slaunwhite; Terry R Wightman; Shelley Secor-Socha; Sara K Misra; Timothy P Bushnell; Ann-Marie Reynolds; Rita M Ryan; Sally A Quataert; Gloria S Pryhuber; Thomas J Mariani
Journal:  J Immunol Methods       Date:  2016-07-18       Impact factor: 2.303

Review 3.  Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity.

Authors:  Sonwabile Dzanibe; Heather B Jaspan; Michael Z Zulu; Agano Kiravu; Clive M Gray
Journal:  J Leukoc Biol       Date:  2018-12-21       Impact factor: 4.962

Review 4.  The initiation of metabolic inflammation in childhood obesity.

Authors:  Kanakadurga Singer; Carey N Lumeng
Journal:  J Clin Invest       Date:  2017-01-03       Impact factor: 14.808

5.  Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.

Authors:  J Pagel; A Hartz; J Figge; C Gille; S Eschweiler; K Petersen; L Schreiter; J Hammer; C M Karsten; D Friedrich; E Herting; W Göpel; J Rupp; C Härtel
Journal:  Clin Exp Immunol       Date:  2016-06-12       Impact factor: 4.330

6.  Silica exposure and chronic virus infection synergistically promote lupus-like systemic autoimmunity in mice with low genetic predisposition.

Authors:  Rosana Gonzalez-Quintial; Jessica M Mayeux; Dwight H Kono; Argyrios N Theofilopoulos; Kenneth M Pollard; Roberto Baccala
Journal:  Clin Immunol       Date:  2019-06-05       Impact factor: 3.969

7.  Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype.

Authors:  Natascha Köstlin; Margit Vogelmann; Bärbel Spring; Julian Schwarz; Judith Feucht; Christoph Härtel; Thorsten W Orlikowsky; Christian F Poets; Christian Gille
Journal:  Immunology       Date:  2017-06-08       Impact factor: 7.397

8.  Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.

Authors:  Matthew A Pettengill; Simon D van Haren; Ning Li; David J Dowling; Ilana Bergelson; Jop Jans; Gerben Ferwerda; Ofer Levy
Journal:  Innate Immun       Date:  2016-06-01       Impact factor: 2.680

Review 9.  Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.

Authors:  Suhas Sureshchandra; Nicole E Marshall; Ilhem Messaoudi
Journal:  J Leukoc Biol       Date:  2019-09-04       Impact factor: 4.962

Review 10.  Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Authors:  Andrea Danese; Stephanie J Lewis
Journal:  Neuropsychopharmacology       Date:  2016-09-15       Impact factor: 7.853
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