| Literature DB >> 21734174 |
Guzman Sanchez-Schmitz1, Ofer Levy.
Abstract
Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.Entities:
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Year: 2011 PMID: 21734174 PMCID: PMC4108897 DOI: 10.1126/scitranslmed.3001880
Source DB: PubMed Journal: Sci Transl Med ISSN: 1946-6234 Impact factor: 17.956