Sandrine Censabella1, Stefan Claes2, Marc Orlandini3, Roel Braekers4, Herbert Thijs5, Paul Bulens6. 1. Jessa Hospital, Oncology Department (Datamanagement), Stadsomvaart 11, 3500 Hasselt, Belgium. Electronic address: Sandrine.Censabella@jessazh.be. 2. Limburg Oncology Centre, Stadsomvaart 11, 3500 Hasselt, Belgium. Electronic address: Stefan.Claes@jessazh.be. 3. Limburg Oncology Centre, Stadsomvaart 11, 3500 Hasselt, Belgium. Electronic address: Marc.Orlandini@jessazh.be. 4. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1, B3590 Diepenbeek, Belgium; Catholic University of Leuven, Kapucijnenvoer 35, Blok D, Bus 7001, B3000 Leuven, Belgium. Electronic address: roel.braekers@uhasselt.be. 5. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1, B3590 Diepenbeek, Belgium; Catholic University of Leuven, Kapucijnenvoer 35, Blok D, Bus 7001, B3000 Leuven, Belgium. Electronic address: herbert.thijs@uhasselt.be. 6. Limburg Oncology Centre, Stadsomvaart 11, 3500 Hasselt, Belgium. Electronic address: Paul.Bulens@jessazh.be.
Abstract
PURPOSE: Dermatitis is a very frequent and distressing side effect of radiation therapy that may necessitate a treatment interruption when evolving towards more severe forms such as moist desquamation (MD). The aim of this study was to compare the efficacy of two topical agents, a dexpanthenol cream vs a hydroactive colloid gel combining absorbing and moisturising properties, in preventing MD in breast cancer patients. METHODS: This retrospective study compared two successive groups of breast cancer patients undergoing radiotherapy after breast-sparing surgery between 2008 and 2012. A group of 267 patients applied a 5% dexpanthenol cream on the irradiated zone throughout the course of their radiotherapy. Another group of 216 patients applied first the dexpanthenol cream then replaced it by the hydroactive colloid gel after 11-14 days of radiotherapy. Radiation treatment (total dose, technique, and equipment) was the same for the two groups. The clinical outcomes were the occurrence and time to onset of moist desquamation. KEY RESULTS: The overall incidence of MD was significantly lower in patients who applied the hydroactive colloid gel (16%) than in those who applied the dexpanthenol cream (32%, odds-ratio = 0.35). Also, MD occurred significantly later with the hydroactive colloid gel than with the dexpanthenol cream (hazard ratio = 0.39). CONCLUSIONS: Compared with the dexpanthenol cream, the hydroactive colloid gel significantly reduced the risk of developing MD in patients undergoing radiotherapy for breast cancer. These promising results warrant further research on the efficacy of hydroactive colloid gels in managing radiation dermatitis.
PURPOSE:Dermatitis is a very frequent and distressing side effect of radiation therapy that may necessitate a treatment interruption when evolving towards more severe forms such as moist desquamation (MD). The aim of this study was to compare the efficacy of two topical agents, a dexpanthenol cream vs a hydroactive colloid gel combining absorbing and moisturising properties, in preventing MD in breast cancerpatients. METHODS: This retrospective study compared two successive groups of breast cancerpatients undergoing radiotherapy after breast-sparing surgery between 2008 and 2012. A group of 267 patients applied a 5% dexpanthenol cream on the irradiated zone throughout the course of their radiotherapy. Another group of 216 patients applied first the dexpanthenol cream then replaced it by the hydroactive colloid gel after 11-14 days of radiotherapy. Radiation treatment (total dose, technique, and equipment) was the same for the two groups. The clinical outcomes were the occurrence and time to onset of moist desquamation. KEY RESULTS: The overall incidence of MD was significantly lower in patients who applied the hydroactive colloid gel (16%) than in those who applied the dexpanthenol cream (32%, odds-ratio = 0.35). Also, MD occurred significantly later with the hydroactive colloid gel than with the dexpanthenol cream (hazard ratio = 0.39). CONCLUSIONS: Compared with the dexpanthenol cream, the hydroactive colloid gel significantly reduced the risk of developing MD in patients undergoing radiotherapy for breast cancer. These promising results warrant further research on the efficacy of hydroactive colloid gels in managing radiation dermatitis.
Authors: Jonatas Gomes Barbosa da Silva; Diogo Timóteo Costa; Iago Dillion Lima Cavalcanti; Mariane Cajubá de Britto Lira Nogueira; Diego Augusto Lopes Oliveira Journal: Can Oncol Nurs J Date: 2022-04-01
Authors: Jonatas Gomes Barbosa da Silva; Diogo Timóteo Costa; Iago Dillion Lima Cavalcanti; Mariane Cajubá de Britto Lira Nogueira; Diego Augusto Lopes Oliveira Journal: Can Oncol Nurs J Date: 2022-04-01
Authors: Agnieszka Baic; Dominika Plaza; Barbara Lange; Łukasz Michalecki; Agata Stanek; Anna Kowalczyk; Krzysztof Ślosarek; Armand Cholewka Journal: Int J Environ Res Public Health Date: 2022-06-04 Impact factor: 4.614
Authors: Dominika Plaza; Agnieszka Baic; Barbara Lange; Agata Stanek; Krzysztof Ślosarek; Anna Kowalczyk; Armand Cholewka Journal: Int J Environ Res Public Health Date: 2021-01-13 Impact factor: 3.390
Authors: Agnieszka Baic; Dominika Plaza; Barbara Lange; Łukasz Michalecki; Agata Stanek; Krzysztof Ślosarek; Armand Cholewka Journal: Int J Environ Res Public Health Date: 2022-02-28 Impact factor: 3.390