Literature DB >> 24874955

The soft underbelly of tumor cells.

Yufeng Shi1, S Kyun Lim1, Luis F Parada1.   

Abstract

In a recent Cell paper, Kitambi and colleagues identify a small molecule (Vacquinol-1) that has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.

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Year:  2014        PMID： 24874955      PMCID： PMC4123293          DOI： 10.1038/cr.2014.72

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

Review 1.  Macropinocytosis: an endocytic pathway for internalising large gulps.

Authors:  Jet Phey Lim; Paul A Gleeson
Journal:  Immunol Cell Biol       Date:  2011-03-22       Impact factor: 5.126

2.  Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice.

Authors:  J K Lee; W S Hwang; Y D Lee; P L Han
Journal:  Brain Res Mol Brain Res       Date:  1999-03-20

Review 3.  Primary and secondary glioblastomas: from concept to clinical diagnosis.

Authors:  P Kleihues; H Ohgaki
Journal:  Neuro Oncol       Date:  1999-01       Impact factor: 12.300

4.  Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.

Authors:  Steven C Cunningham; Eike Gallmeier; Tomas Hucl; David A Dezentje; Eric S Calhoun; Geppino Falco; Kotb Abdelmohsen; Myriam Gorospe; Scott E Kern
Journal:  Cancer Res       Date:  2006-06-01       Impact factor: 12.701

5.  RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Authors:  Satish Srinivas Kitambi; Enrique M Toledo; Dmitry Usoskin; Shimei Wee; Aditya Harisankar; Richard Svensson; Kristmundur Sigmundsson; Christina Kalderén; Mia Niklasson; Soumi Kundu; Sergi Aranda; Bengt Westermark; Lene Uhrbom; Michael Andäng; Peter Damberg; Sven Nelander; Ernest Arenas; Per Artursson; Julian Walfridsson; Karin Forsberg Nilsson; Lars G J Hammarström; Patrik Ernfors
Journal:  Cell       Date:  2014-03-20       Impact factor: 41.582

Review 6.  Role of mitogen-activated protein kinase kinase 4 in cancer.

Authors:  A J Whitmarsh; R J Davis
Journal:  Oncogene       Date:  2007-05-14       Impact factor: 9.867

7.  Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

Authors:  B Dérijard; J Raingeaud; T Barrett; I H Wu; J Han; R J Ulevitch; R J Davis
Journal:  Science       Date:  1995-02-03       Impact factor: 47.728

8.  Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Authors: 
Journal:  Nature       Date:  2008-09-04       Impact factor: 49.962

Review 9.  The 2007 WHO classification of tumours of the central nervous system.

Authors:  David N Louis; Hiroko Ohgaki; Otmar D Wiestler; Webster K Cavenee; Peter C Burger; Anne Jouvet; Bernd W Scheithauer; Paul Kleihues
Journal:  Acta Neuropathol       Date:  2007-07-06       Impact factor: 17.088

10.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Authors:  Cosimo Commisso; Shawn M Davidson; Rengin G Soydaner-Azeloglu; Seth J Parker; Jurre J Kamphorst; Sean Hackett; Elda Grabocka; Michel Nofal; Jeffrey A Drebin; Craig B Thompson; Joshua D Rabinowitz; Christian M Metallo; Matthew G Vander Heiden; Dafna Bar-Sagi
Journal:  Nature       Date:  2013-05-12       Impact factor: 49.962
  10 in total
  1 in total

1.  Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.

Authors:  Hao Chang; Jingning Zhang; Zengli Miao; Yasuo Ding; Xing Xu; Xudong Zhao; Peng Xu; Qing Wang; Yuchang Lin
Journal:  Cell Mol Neurobiol       Date:  2017-03-20       Impact factor: 5.046
  1 in total

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