Literature DB >> 24873032

Cytotoxic polyacetylenes from the Red Sea sponge Siphonochalina siphonella.

Seif-Eldin N Ayyad, Rihab Angawy, Waliled M Alarif, Esraa A Saqer, Farid A Badria.   

Abstract

Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11.7 microM, respectively.

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Year:  2014        PMID： 24873032     DOI： 10.5560/znc.2013-0088

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  3 in total

Review 1.  Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.

Authors:  Mohamed Elamir F Hegazy; Tarik A Mohamed; Montaser A Alhammady; Alaa M Shaheen; Eman H Reda; Abdelsamed I Elshamy; Mina Aziz; Paul W Paré
Journal:  Mar Drugs       Date:  2015-05-20       Impact factor: 5.118

2.  Cytotoxic Metabolites from Callyspongia siphonella Display Antiproliferative Activity by Inducing Apoptosis in HCT-116 Cells.

Authors:  Tariq R A Sobahi; Seif-Eldin N Ayyad; Ahmed Abdel-Lateff; Mardi M Algandaby; Hajer S Alorfi; Ashraf B Abdel-Naim
Journal:  Pharmacogn Mag       Date:  2017-04-07       Impact factor: 1.085

Review 3.  Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data.

Authors:  Lucas Hilário Nogueira de Sousa; Rusceli Diego de Araújo; Déborah Sousa-Fontoura; Fabrício Gava Menezes; Renata Mendonça Araújo
Journal:  Mar Drugs       Date:  2021-11-26       Impact factor: 5.118
  3 in total

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