Literature DB >> 24871900

Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents.

Koneni V Sashidhara1, Ranga Prasad Dodda2, Ravi Sonkar3, Gopala Reddy Palnati2, Gitika Bhatia3.   

Abstract

A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antidyslipidemic activity; Antioxidant activity; Indole-chalcone fibrates; LPL activity; Triton model

Mesh：

Substances：

Year:  2014        PMID： 24871900     DOI： 10.1016/j.ejmech.2014.04.085

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Increased fecal indole concentration in women with gestational diabetes: a pilot study.

Authors:  Marija Trajkova; Katja Molan; Maja Zugan; Jerneja Ambrožič Avguštin; Marjanca Starčič Erjavec; Darja Žgur Bertok; Draženka Pongrac Barlovič
Journal:  Acta Diabetol       Date:  2020-11-20       Impact factor: 4.280

Review 2.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

3.  Novel indolyl-chalcones target stathmin to induce cancer cell death.

Authors:  Barbara Wegiel; Yiqiang Wang; Mailin Li; Finith Jernigan; Lijun Sun
Journal:  Cell Cycle       Date:  2016-03-17       Impact factor: 4.534

4.  Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.

Authors:  Yiqiang Wang; Andreas Hedblom; Steffi K Koerner; Mailin Li; Finith E Jernigan; Barbara Wegiel; Lijun Sun
Journal:  Bioorg Med Chem Lett       Date:  2016-10-24       Impact factor: 2.823

5.  Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages.

Authors:  I-Jou Teng; Min-Chien Tsai; Shao-Fu Shih; Bi-Feng Tsuei; Hsin Chang; Yi-Ping Chuang; Chin-Sheng Lin; Ching-Yuh Chern; Sy-Jou Chen
Journal:  Molecules       Date:  2018-07-03       Impact factor: 4.411

Review 6.  Chalcone Derivatives: Promising Starting Points for Drug Design.

Authors:  Marcelo N Gomes; Eugene N Muratov; Maristela Pereira; Josana C Peixoto; Lucimar P Rosseto; Pedro V L Cravo; Carolina H Andrade; Bruno J Neves
Journal:  Molecules       Date:  2017-07-25       Impact factor: 4.411

7.  Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.

Authors:  Peter A Halim; Rasha A Hassan; Khaled O Mohamed; Soha O Hassanin; Mona G Khalil; Amr M Abdou; Eman O Osman
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

8.  The Small Molecule PPARγ Agonist GL516 Induces Feeding-Stimulatory Effects in Hypothalamus Cells Hypo-E22 and Isolated Hypothalami.

Authors:  Annalisa Chiavaroli; Viviana di Giacomo; Barbara De Filippis; Amelia Cataldi; Claudio Ferrante; Letizia Giampietro
Journal:  Molecules       Date:  2022-07-30       Impact factor: 4.927

9.  Synthesis of 3-alkenylindoles through regioselective C-H alkenylation of indoles by a ruthenium nanocatalyst.

Authors:  Abhijit Paul; Debnath Chatterjee; Srirupa Banerjee; Somnath Yadav
Journal:  Beilstein J Org Chem       Date:  2020-01-29       Impact factor: 2.883
  9 in total

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