Literature DB >> 24871215

The molecular bacterial load assay replaces solid culture for measuring early bactericidal response to antituberculosis treatment.

Isobella Honeyborne1, Bariki Mtafya2, Patrick P J Phillips3, Michael Hoelscher4, Elias N Ntinginya2, Anke Kohlenberg2, Andrea Rachow4, Gabriel Rojas-Ponce2, Timothy D McHugh5, Norbert Heinrich4.   

Abstract

We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The MBL assay provides early information on the rate of decline in bacterial load and has technical advantages over culture in either form.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24871215      PMCID： PMC4136187          DOI： 10.1128/JCM.01128-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  18 in total

1.  A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.

Authors:  Stephen H Gillespie; Roland D Gosling; Bambos M Charalambous
Journal:  Am J Respir Crit Care Med       Date:  2002-07-01       Impact factor: 21.405

2.  Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents.

Authors:  A H Diacon; J S Maritz; A Venter; P D van Helden; R Dawson; P R Donald
Journal:  Clin Microbiol Infect       Date:  2011-08-18       Impact factor: 8.067

3.  Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment.

Authors:  Sven O Friedrich; Andrea Rachow; Elmar Saathoff; Kasha Singh; Chacha D Mangu; Rodney Dawson; Patrick Pj Phillips; Amour Venter; Anna Bateson; Catharina C Boehme; Norbert Heinrich; Robert D Hunt; Martin J Boeree; Alimuddin Zumla; Timothy D McHugh; Stephen H Gillespie; Andreas H Diacon; Michael Hoelscher
Journal:  Lancet Respir Med       Date:  2013-07-01       Impact factor: 30.700

4.  Formation and resuscitation of "non-culturable" cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase.

Authors:  M O Shleeva; K Bagramyan; M V Telkov; G V Mukamolova; M Young; D B Kell; A S Kaprelyants
Journal:  Microbiology       Date:  2002-05       Impact factor: 2.777

5.  Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.

Authors:  Joanna C Betts; Pauline T Lukey; Linda C Robb; Ruth A McAdam; Ken Duncan
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

6.  Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity.

Authors:  Xavier A Kayigire; Sven O Friedrich; Amour Venter; Rodney Dawson; Stephen H Gillespie; Martin J Boeree; Norbert Heinrich; Michael Hoelscher; Andreas H Diacon
Journal:  J Clin Microbiol       Date:  2013-04-17       Impact factor: 5.948

7.  Resuscitation-promoting factors reveal an occult population of tubercle Bacilli in Sputum.

Authors:  Galina V Mukamolova; Obolbek Turapov; Joanne Malkin; Gerrit Woltmann; Michael R Barer
Journal:  Am J Respir Crit Care Med       Date:  2009-10-29       Impact factor: 21.405

8.  Probability of negative mycobacterium tuberculosis complex cultures based on time to detection of positive cultures: a multicenter evaluation of commercial-broth-based culture systems.

Authors:  Frances C Tyrrell; Gary E Budnick; Thor Elliott; Laura Gillim-Ross; Mary V Hildred; Peggy Mahlmeister; Nicole Parrish; Michael Pentella; Jolene Vanneste; Yun F Wayne Wang; Angela M Starks
Journal:  J Clin Microbiol       Date:  2012-07-25       Impact factor: 5.948

9.  Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days.

Authors:  Amina Jindani; Caroline J Doré; Denis A Mitchison
Journal:  Am J Respir Crit Care Med       Date:  2003-01-06       Impact factor: 21.405

10.  Serial counts of Mycobacterium tuberculosis in sputum as surrogate markers of the sterilising activity of rifampicin and pyrazinamide in treating pulmonary tuberculosis.

Authors:  R Brindle; J Odhiambo; D Mitchison
Journal:  BMC Pulm Med       Date:  2001       Impact factor: 3.317
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  36 in total

1.  Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture.

Authors:  Robin J Svensson; Wilber Sabiiti; Gibson S Kibiki; Nyanda E Ntinginya; Nilesh Bhatt; Geraint Davies; Stephen H Gillespie; Ulrika S H Simonsson
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

2.  Molecular Bacterial Load Assay Concurs with Culture on NaOH-Induced Loss of Mycobacterium tuberculosis Viability.

Authors:  Bariki Mtafya; Wilber Sabiiti; Issa Sabi; Joseph John; Emanuel Sichone; Nyanda E Ntinginya; Stephen H Gillespie
Journal:  J Clin Microbiol       Date:  2019-06-25       Impact factor: 5.948

3.  Heat Inactivation Renders Sputum Safe and Preserves Mycobacterium tuberculosis RNA for Downstream Molecular Tests.

Authors:  Wilber Sabiiti; Khalide Azam; Ezembro Esmeraldo; Nilesh Bhatt; Andrea Rachow; Stephen H Gillespie
Journal:  J Clin Microbiol       Date:  2019-03-28       Impact factor: 5.948

Review 4.  Tuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies.

Authors:  Jan Heyckendorf; Sophia B Georghiou; Nicole Frahm; Norbert Heinrich; Irina Kontsevaya; Maja Reimann; David Holtzman; Marjorie Imperial; Daniela M Cirillo; Stephen H Gillespie; Morten Ruhwald
Journal:  Clin Microbiol Rev       Date:  2022-03-21       Impact factor: 50.129

Review 5.  Assessment of treatment response in tuberculosis.

Authors:  Neesha Rockwood; Elsa du Bruyn; Thomas Morris; Robert J Wilkinson
Journal:  Expert Rev Respir Med       Date:  2016-03-31       Impact factor: 3.772

Review 6.  Challenges in the clinical assessment of novel tuberculosis drugs.

Authors:  Kelly E Dooley; Patrick P J Phillips; Payam Nahid; Michael Hoelscher
Journal:  Adv Drug Deliv Rev       Date:  2016-01-28       Impact factor: 15.470

7.  Gridlock from Diagnosis to Treatment of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania: Illuminating Potential Factors for Possible Intervention.

Authors:  Alphonce A Liyoyo; Scott K Heysell; Riziki M Kisonga; Johnson J Lyimo; Liberate J Mleoh; Beatrice K Mutayoba; Isaack A Lekule; Blandina T Mmbaga; Gibson S Kibiki; Stellah G Mpagama
Journal:  East Afr Health Res J       Date:  2017-03-01

8.  Evaluation of the molecular bacterial load assay for detecting viable Mycobacterium tuberculosis in cerebrospinal fluid before and during tuberculous meningitis treatment.

Authors:  Hoang Thanh Hai; Wilber Sabiiti; Do Dang Anh Thu; Nguyen Hoan Phu; Stephen H Gillespie; Guy E Thwaites; Nguyen Thuy Thuong Thuong
Journal:  Tuberculosis (Edinb)       Date:  2021-04-29       Impact factor: 3.131

9.  Beyond the Numbers: Interpreting WHO's Global Tuberculosis Report 2016 to Inform TB Policy and Practice in the East African Community.

Authors:  Wilber Sabiiti
Journal:  East Afr Health Res J       Date:  2017-03-01

Review 10.  Molecular bacterial load assay versus culture for monitoring treatment response in adults with tuberculosis.

Authors:  Bibie Said; Loveness Charlie; Emnet Getachew; Catherine Lydiah Wanjiru; Mekdelawit Abebe; Tsegahun Manyazewal
Journal:  SAGE Open Med       Date:  2021-07-17
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