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Literature DB >> 24867813

miRNAs at the interface of cellular stress and disease.

Abstract

microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

Entities: Disease

Keywords: cellular stress; dicer; disease; micrornas; stress granules

Mesh：

Substances：
MicroRNAs

Year: 2014 PMID： 24867813 PMCID： PMC4194087 DOI： 10.15252/embj.201488142

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

133 in total

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Journal: Nat Genet Date: 2006-06 Impact factor: 38.330

Review 2. MicroRNAs in stress signaling and human disease.

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Journal: Cell Date: 2012-03-16 Impact factor: 41.582

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Journal: J Biol Chem Date: 1993-06-15 Impact factor: 5.157

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Journal: Proc Natl Acad Sci U S A Date: 2012-02-09 Impact factor: 11.205

5. miR-375 maintains normal pancreatic alpha- and beta-cell mass.

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Journal: Proc Natl Acad Sci U S A Date: 2009-03-16 Impact factor: 11.205

6. miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.

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Journal: Cell Date: 2013-12-19 Impact factor: 41.582

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Journal: Nat Neurosci Date: 2009-03-29 Impact factor: 24.884

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Journal: J Cell Biol Date: 1999-12-27 Impact factor: 10.539

9. MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness?

Authors: Carolina Ibáñez-Ventoso; Monica Driscoll
Journal: Curr Genomics Date: 2009-05 Impact factor: 2.236

10. Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.

Authors: Nicolas J Lehrbach; Cecilia Castro; Kenneth J Murfitt; Cei Abreu-Goodger; Julian L Griffin; Eric A Miska
Journal: RNA Date: 2012-10-24 Impact factor: 4.942

48 in total

Review 1. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye.

Authors: Thomas R Sundermeier; Krzysztof Palczewski
Journal: FASEB J Date: 2015-09-23 Impact factor: 5.191

2. Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance.

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Journal: J Biol Chem Date: 2015-08-13 Impact factor: 5.157

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Authors: Thomas F Duchaine; Marc R Fabian
Journal: Cold Spring Harb Perspect Biol Date: 2019-03-01 Impact factor: 10.005

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Journal: Elife Date: 2018-07-19 Impact factor: 8.140

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Journal: Elife Date: 2017-09-05 Impact factor: 8.140

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Journal: Br J Pharmacol Date: 2017-05-10 Impact factor: 8.739

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Journal: Biochem Cell Biol Date: 2014-10-13 Impact factor: 3.626

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Journal: Atherosclerosis Date: 2016-09-22 Impact factor: 5.162

10. Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.

Authors: Anna Emde; Chen Eitan; Lee-Loung Liou; Ryan T Libby; Natali Rivkin; Iddo Magen; Irit Reichenstein; Hagar Oppenheim; Raya Eilam; Aurelio Silvestroni; Betty Alajajian; Iddo Z Ben-Dov; Julianne Aebischer; Alon Savidor; Yishai Levin; Robert Sons; Scott M Hammond; John M Ravits; Thomas Möller; Eran Hornstein
Journal: EMBO J Date: 2015-09-01 Impact factor: 11.598