| Literature DB >> 24863197 |
Xiaorui Gao1, Le Chen2, Juan Xie3, Yaobing Yin3, Tao Chang3, Yancong Duan3, Nan Jiang3.
Abstract
A new drug delivery system for vitamin C (VC), Ca/Al layered double hydroxide (LDH), is demonstrated in this work. VC anions were intercalated successfully in the Ca/Al LDH gallery by a coprecipitation method. The interlayer space of 9.8Å suggests that VC anions are vertical to the LDH layers in the form of interdigitated bilayer. The loading of VC in LDH is 36.4wt.%. The thermal stability of VC is significantly enhanced after intercalation. In vitro VC release results show that the release time of VC in a phosphate buffer at pH7.4 was significantly extended, and the maximal percentage of VC released is 80% of the total. The Avrami-Erofe'ev equation most satisfactorily explains the release kinetics of VC, which is that the release of VC is mainly dominated by the ion-exchange reaction.Entities:
Keywords: Controlled release; Drug delivery system; Layered double hydroxide; Thermal stability; Vitamin C
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Year: 2014 PMID： 24863197 DOI： 10.1016/j.msec.2014.02.028
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328