Literature DB >> 24862054

Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata.

G Uddin1, A Sadat1, B S Siddiqui2.   

Abstract

In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-galloylbergenin were 7.45±0.2 μg/mL and 5.39±0.28 μg/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 μM. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-galloylbergenin was found more potent (CAHT: 940.04±115.30) as compared to α-tocopherol (CAHT: 552.4±27.91).

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Year:  2014        PMID： 24862054

Source DB:  PubMed          Journal:  Trop Biomed        ISSN： 0127-5720            Impact factor:   0.623


  7 in total

1.  Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis.

Authors:  Xue-jiao Gao; Meng-yao Guo; Ze-cai Zhang; Tian-cheng Wang; Yong-guo Cao; Nai-sheng Zhang
Journal:  Inflammation       Date:  2015       Impact factor: 4.092

2.  Major bioactive phenolics in Bergenia species from the Indian Himalayan region: Method development, validation and quantitative estimation using UHPLC-QqQLIT-MS/MS.

Authors:  Renu Pandey; Brijesh Kumar; Baleshwar Meena; Mukesh Srivastava; Tripti Mishra; Vandana Tiwari; Mahesh Pal; Narayanan K Nair; Dalip K Upreti; Tikam Singh Rana
Journal:  PLoS One       Date:  2017-07-27       Impact factor: 3.240

3.  Evaluation of in vitro and in vivo antileishmanial potential of bergenin rich Bergenia ligulata (Wall.) Engl. root extract against visceral leishmaniasis in inbred BALB/c mice through immunomodulation.

Authors:  Rupinder Kaur; Sukhbir Kaur
Journal:  J Tradit Complement Med       Date:  2017-06-27

4.  Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor.

Authors:  Bishnu Prasad Pandey; Suman Prakash Pradhan; Kapil Adhikari; Saroj Nepal
Journal:  BMC Complement Med Ther       Date:  2020-06-26

5.  Development and validation of UPLC-PDA method for concurrent analysis of bergenin and menisdaurin in aerial parts of Flueggea virosa (Roxb. ex Willd.).

Authors:  Afzal Hussain; Perwez Alam; Nasir Ali Siddiqui; Mohamed Fahad Alajmi; Md Tabish Rehman; Mohd Abul Kalam; Adnan Jathlan Al-Rehaily
Journal:  Saudi Pharm J       Date:  2018-05-22       Impact factor: 4.330

6.  Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis.

Authors:  Hamayun Khan; Hazrat Amin; Asad Ullah; Sumbal Saba; Jamal Rafique; Khalid Khan; Nasir Ahmad; Syed Lal Badshah
Journal:  Oxid Med Cell Longev       Date:  2016-02-22       Impact factor: 6.543

7.  Hydroethanolic extract from Endopleura uchi (Huber) Cuatrecasas and its marker bergenin: Toxicological and pharmacokinetic studies in silico and in vivo on zebrafish.

Authors:  Beatriz Martins de Sá Hyacienth; Karyny Roberta Tavares Picanço; Brenda Lorena Sánchez-Ortiz; Luciane Barros Silva; Arlindo César Matias Pereira; Larissa Daniele Machado Góes; Raphaelle Sousa Borges; Rodrigo Cardoso Ataíde; Cleydson Breno Rodrigues Dos Santos; Helison de Oliveira Carvalho; Gloria Melisa Gonzalez Anduaga; Andrés Navarrete; José Carlos Tavares Carvalho
Journal:  Toxicol Rep       Date:  2020-01-27
  7 in total

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