Literature DB >> 24859469

Examining the impact of gene variants on histone lysine methylation.

Capucine Van Rechem1, Johnathan R Whetstine2.   

Abstract

In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  EZH2; Histone; KDM; KMT; SNP; Somatic mutation

Mesh：

Substances：

Year:  2014        PMID： 24859469      PMCID： PMC4752941          DOI： 10.1016/j.bbagrm.2014.05.014

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  134 in total

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Journal:  Epigenetics Chromatin       Date:  2016-10-26       Impact factor: 4.954
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