Jae H Kang1, Janey L Wiggs2, Louis R Pasquale3. 1. Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts. Electronic address: nhjhk@channing.harvard.edu. 2. Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts. 3. Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts.
Abstract
PURPOSE: To evaluate the relation between time spent outdoors at various life periods and risk of exfoliation glaucoma or exfoliation glaucoma suspect. DESIGN: Retrospective cohort study in the United States. METHODS: Participants (49 033 women in the Nurses Health Study and 20 066 men in the Health Professionals Follow-up Study) were 60+ years old, were free of glaucoma and cataract, reported eye examinations, and completed questions about time spent outdoors in direct sunlight at midday at 3 life periods: high school to age 24 years, age 25-35 years, and age 36-59 years (asked in 2006 in women and 2008 in men). Participants were followed biennially with mailed questionnaires from 1980 women/1986 men to 2010. Incident cases (223 women and 38 men) were confirmed with medical records. Cohort-specific multivariable-adjusted rate ratios from Cox proportional hazards models were estimated and pooled with meta-analysis. RESULTS: Although no association was observed with greater time spent outdoors in the ages of 25-35 or ages 36-59 years, the pooled multivariable-adjusted rate ratios for ≥11 hours per week spent outdoors in high school to age 24 years compared with ≤5 hours per week was 2.00 (95% confidence interval = 1.30, 3.08; P for linear trend = .001). In women, this association was stronger in those who resided in the southern geographic tier in young adulthood (P for interaction = .07). CONCLUSIONS: Greater time spent outdoors in young adulthood was associated with risk of exfoliation glaucoma or exfoliation glaucoma suspect, supporting an etiologic role of early exposures to climatic factors.
PURPOSE: To evaluate the relation between time spent outdoors at various life periods and risk of exfoliation glaucoma or exfoliation glaucoma suspect. DESIGN: Retrospective cohort study in the United States. METHODS:Participants (49 033 women in the Nurses Health Study and 20 066 men in the Health Professionals Follow-up Study) were 60+ years old, were free of glaucoma and cataract, reported eye examinations, and completed questions about time spent outdoors in direct sunlight at midday at 3 life periods: high school to age 24 years, age 25-35 years, and age 36-59 years (asked in 2006 in women and 2008 in men). Participants were followed biennially with mailed questionnaires from 1980 women/1986 men to 2010. Incident cases (223 women and 38 men) were confirmed with medical records. Cohort-specific multivariable-adjusted rate ratios from Cox proportional hazards models were estimated and pooled with meta-analysis. RESULTS: Although no association was observed with greater time spent outdoors in the ages of 25-35 or ages 36-59 years, the pooled multivariable-adjusted rate ratios for ≥11 hours per week spent outdoors in high school to age 24 years compared with ≤5 hours per week was 2.00 (95% confidence interval = 1.30, 3.08; P for linear trend = .001). In women, this association was stronger in those who resided in the southern geographic tier in young adulthood (P for interaction = .07). CONCLUSIONS: Greater time spent outdoors in young adulthood was associated with risk of exfoliation glaucoma or exfoliation glaucoma suspect, supporting an etiologic role of early exposures to climatic factors.
Authors: R Krishnadas; Praveen K Nirmalan; R Ramakrishnan; R D Thulasiraj; Joanne Katz; James M Tielsch; David S Friedman; Alan L Robin Journal: Am J Ophthalmol Date: 2003-06 Impact factor: 5.258
Authors: Jeff J Huang; Jack E Geduldig; Erica B Jacobs; Tak Yee T Tai; Sumayya Ahmad; Nisha Chadha; Douglas F Buxton; Kateki Vinod; Barbara M Wirostko; Jae H Kang; Janey L Wiggs; Robert Ritch; Louis R Pasquale Journal: Ophthalmol Glaucoma Date: 2022-04-22
Authors: Jae H Kang; Trang VoPham; Francine Laden; Bernard A Rosner; Barbara Wirostko; Robert Ritch; Janey L Wiggs; Abrar Qureshi; Hongmei Nan; Louis R Pasquale Journal: J Glaucoma Date: 2020-06 Impact factor: 2.503
Authors: Ahmad M Mansour; Anastasios G P Konstas; Hana A Mansour; Abdul R Charbaji; Khalil M El Jawhari Journal: Middle East Afr J Ophthalmol Date: 2021-04-30