Jae H Kang1, Trang VoPham1,2, Francine Laden1,3,4, Bernard A Rosner1,5, Barbara Wirostko6, Robert Ritch7, Janey L Wiggs8, Abrar Qureshi9,10, Hongmei Nan11,12, Louis R Pasquale1,7,13. 1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital. 2. Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 3. Departments of Epidemiology. 4. Environmental Health. 5. Biostatistics, Harvard T. H. Chan School of Public Health. 6. Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, UT. 7. Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai. 8. Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA. 9. Department of Dermatology, the Warren Alpert Medical School of Brown University. 10. Department of Epidemiology, Brown School of Public Health, Providence, RI. 11. Department of Epidemiology, Richard M. Fairbanks School of Public Health. 12. Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN. 13. Department of Ophthalmology, Eye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Abstract
PRECIS: In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE: The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XFG. METHODS: We performed a cohort study of US women (n=79,102; 1980-2014) and men (n=41,205; 1986-2014), aged 40+ years and at risk for glaucoma who reported eye examinations. From 1984 (women)/1988 (men), we asked about basal cell carcinoma or squamous cell carcinoma history separately; in prior years, we asked about any NMSC history in a single question. Squamous cell carcinoma was confirmed with histopathology reports while basal cell carcinoma and any early (<1984/<1988) NMSC history was self-reported. Incident XFG cases (362 women and 83 men) were confirmed with medical records. Using pooled data, we estimated multivariable-adjusted relative risks [MVRRs; 95% confidence intervals (CIs)] with Cox proportional hazards models that were stratified by age (in mo), 2-year time period at risk and average lifetime residential latitude. RESULTS: In multivariable-adjusted analyses, we observed a 40% higher XFG risk with any NMSC history (MVRR=1.40; 95% CI=1.08-1.82); the association was observed even with 4 and 8-year lags in NMSC history. Also, the NMSC association was stronger in younger (below 65 y; MVRR=2.56; 95% CI=1.62-4.05) versus older participants (65 y and above; MVRR=1.25; 95% CI=0.94-1.66; P for interaction=0.01) and those living in the northern latitudes (≥42°N; MVRR=1.92; 95% CI=1.28-2.88) versus more southern latitudes (<42°N; MVRR=1.19; 95% CI=0.86-1.66; P for interaction=0.04). CONCLUSION: NMSC was associated with higher XFG risk, particularly among younger participants and those living in the Northern US.
PRECIS: In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE: The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XFG. METHODS: We performed a cohort study of US women (n=79,102; 1980-2014) and men (n=41,205; 1986-2014), aged 40+ years and at risk for glaucoma who reported eye examinations. From 1984 (women)/1988 (men), we asked about basal cell carcinoma or squamous cell carcinoma history separately; in prior years, we asked about any NMSC history in a single question. Squamous cell carcinoma was confirmed with histopathology reports while basal cell carcinoma and any early (<1984/<1988) NMSC history was self-reported. Incident XFG cases (362 women and 83 men) were confirmed with medical records. Using pooled data, we estimated multivariable-adjusted relative risks [MVRRs; 95% confidence intervals (CIs)] with Cox proportional hazards models that were stratified by age (in mo), 2-year time period at risk and average lifetime residential latitude. RESULTS: In multivariable-adjusted analyses, we observed a 40% higher XFG risk with any NMSC history (MVRR=1.40; 95% CI=1.08-1.82); the association was observed even with 4 and 8-year lags in NMSC history. Also, the NMSC association was stronger in younger (below 65 y; MVRR=2.56; 95% CI=1.62-4.05) versus older participants (65 y and above; MVRR=1.25; 95% CI=0.94-1.66; P for interaction=0.01) and those living in the northern latitudes (≥42°N; MVRR=1.92; 95% CI=1.28-2.88) versus more southern latitudes (<42°N; MVRR=1.19; 95% CI=0.86-1.66; P for interaction=0.04). CONCLUSION: NMSC was associated with higher XFG risk, particularly among younger participants and those living in the Northern US.
Authors: A K Rudkin; K Edussuriya; S Sennanayake; T Senaratne; D Selva; T R Sullivan; R J Casson Journal: Br J Ophthalmol Date: 2008-10-16 Impact factor: 4.638
Authors: G A Colditz; P Martin; M J Stampfer; W C Willett; L Sampson; B Rosner; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1986-05 Impact factor: 4.897
Authors: Padmini Subramaniam; Catherine M Olsen; Bridie S Thompson; David C Whiteman; Rachel E Neale Journal: JAMA Dermatol Date: 2017-02-01 Impact factor: 10.282
Authors: Jeff J Huang; Jack E Geduldig; Erica B Jacobs; Tak Yee T Tai; Sumayya Ahmad; Nisha Chadha; Douglas F Buxton; Kateki Vinod; Barbara M Wirostko; Jae H Kang; Janey L Wiggs; Robert Ritch; Louis R Pasquale Journal: Ophthalmol Glaucoma Date: 2022-04-22
Authors: Jae H Kang; Oana Zeleznik; Lisa Frueh; Jessica Lasky-Su; A Heather Eliassen; Clary Clish; Bernard A Rosner; Louis R Pasquale; Janey L Wiggs Journal: Invest Ophthalmol Vis Sci Date: 2022-08-02 Impact factor: 4.925