Teresa Janevic1, Linda G Kahn2, Paul Landsbergis3, Piera M Cirillo4, Barbara A Cohn4, Xinhua Liu5, Pam Factor-Litvak2. 1. Department of Epidemiology, Rutgers School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, New Jersey. Electronic address: teresa.janevic@rutgers.edu. 2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. 3. Department of Environmental and Occupational Health Sciences, School of Public Health, Downstate Medical Center, State University of New York, Brooklyn, New York. 4. Child Health and Development Studies, Center for Research on Women's and Children's Health, Public Health Institute, Berkeley, California. 5. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Abstract
OBJECTIVE: To evaluate associations between work-related stress, stressful life events, and perceived stress and semen quality. DESIGN: Cross-sectional analysis. SETTING: Northern California. PATIENT(S): 193 men from the Child Health and Development Studies evaluated between 2005-2008. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Measures of stress including job strain, perceived stress, and stressful life events; outcome measures of sperm concentration, percentage of motile sperm, and percentage of morphologically normal sperm. RESULT(S): We found an inverse association between perceived stress score and sperm concentration (estimated coefficient b=-0.09×10(3)/mL; 95% confidence interval [CI]=-0.18, -0.01), motility (b=-0.39; 95% CI=-0.79, 0.01), and morphology (b=-0.14; 95% CI, -0.25, -0.04) in covariate-adjusted linear regression analyses. Men who experienced two or more stressful life events in the past year compared with no stressful events had a lower percentage of motile sperm (b=-8.22; 95% CI, -14.31, -2.13) and a lower percentage of morphologically normal sperm (b=-1.66; 95% CI, -3.35, 0.03) but a similar sperm concentration. Job strain was not associated with semen parameters. CONCLUSION(S): In this first study to examine all three domains of stress, perceived stress and stressful life events but not work-related stress were associated with semen quality.
OBJECTIVE: To evaluate associations between work-related stress, stressful life events, and perceived stress and semen quality. DESIGN: Cross-sectional analysis. SETTING: Northern California. PATIENT(S): 193 men from the Child Health and Development Studies evaluated between 2005-2008. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Measures of stress including job strain, perceived stress, and stressful life events; outcome measures of sperm concentration, percentage of motile sperm, and percentage of morphologically normal sperm. RESULT(S): We found an inverse association between perceived stress score and sperm concentration (estimated coefficient b=-0.09×10(3)/mL; 95% confidence interval [CI]=-0.18, -0.01), motility (b=-0.39; 95% CI=-0.79, 0.01), and morphology (b=-0.14; 95% CI, -0.25, -0.04) in covariate-adjusted linear regression analyses. Men who experienced two or more stressful life events in the past year compared with no stressful events had a lower percentage of motile sperm (b=-8.22; 95% CI, -14.31, -2.13) and a lower percentage of morphologically normal sperm (b=-1.66; 95% CI, -3.35, 0.03) but a similar sperm concentration. Job strain was not associated with semen parameters. CONCLUSION(S): In this first study to examine all three domains of stress, perceived stress and stressful life events but not work-related stress were associated with semen quality.
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