Anshu Shrestha1, Beate Ritz, Michelle Wilhelm, Jiaheng Qiu, Myles Cockburn, Julia E Heck. 1. From the Department of Epidemiology (Drs Shrestha, Ritz, Wilhelm, and Heck), Fielding School of Public Health, University of California Los Angeles Precision Health Economics (Dr Shrestha); Department of Biostatistics (Mr Qiu), Fielding School of Public Health, University of California Los Angeles; and Department of Preventive Medicine (Dr Cockburn), Keck School of Medicine, University of Southern California, Los Angeles.
Abstract
OBJECTIVE: To study prenatal air toxic exposure and Wilms' tumor in children. METHODS: We identified 337 Wilms' tumor cases among children younger than 6 years (1988 to 2008) from the California Cancer Registry, randomly selected 96,514 controls from California birth rolls in 20:1 ratio matched to all cancer cases, then linked birth addresses to air monitors within 15 miles to assess exposures. Multiple logistic regressions were applied to estimate effects. RESULTS: Children prenatally exposed to formaldehyde, polycyclic aromatic hydrocarbons, perchloroethylene, or acetaldehyde in the third trimester had an increased odds of Wilms' tumor per interquartile increase in concentration (odds ratio [95% confidence interval]: 1.28 [1.12 to 1.45], 1.10 [0.99 to 1.22], 1.09 [1.00 to 1.18], 1.25 [1.07 to 1.45], respectively). CONCLUSIONS: We found positive associations for four air toxics. This is the first study of this kind. Future studies are needed to confirm our findings.
OBJECTIVE: To study prenatal air toxic exposure and Wilms' tumor in children. METHODS: We identified 337 Wilms' tumor cases among children younger than 6 years (1988 to 2008) from the California Cancer Registry, randomly selected 96,514 controls from California birth rolls in 20:1 ratio matched to all cancer cases, then linked birth addresses to air monitors within 15 miles to assess exposures. Multiple logistic regressions were applied to estimate effects. RESULTS:Children prenatally exposed to formaldehyde, polycyclic aromatic hydrocarbons, perchloroethylene, or acetaldehyde in the third trimester had an increased odds of Wilms' tumor per interquartile increase in concentration (odds ratio [95% confidence interval]: 1.28 [1.12 to 1.45], 1.10 [0.99 to 1.22], 1.09 [1.00 to 1.18], 1.25 [1.07 to 1.45], respectively). CONCLUSIONS: We found positive associations for four air toxics. This is the first study of this kind. Future studies are needed to confirm our findings.
Authors: Daniel W Goldberg; John P Wilson; Craig A Knoblock; Beate Ritz; Myles G Cockburn Journal: Int J Health Geogr Date: 2008-11-26 Impact factor: 3.918
Authors: Julia E Heck; Jun Wu; Christina Lombardi; Jiaheng Qiu; Travis J Meyers; Michelle Wilhelm; Myles Cockburn; Beate Ritz Journal: Environ Health Perspect Date: 2013-09-10 Impact factor: 9.031
Authors: Julia E Heck; Di He; Carla Janzen; Noah Federman; Jorn Olsen; Beate Ritz; Johnni Hansen Journal: Pediatr Blood Cancer Date: 2018-09-25 Impact factor: 3.167