Literature DB >> 24853636

Implications of Look AHEAD for clinical trials and clinical practice.

R R Wing1.   

Abstract

Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.
© 2014 John Wiley & Sons Ltd.

Entities:  

Keywords:  cardiovascular disease; dietary intervention; type 2 diabetes

Mesh：

Substances：

Year:  2014        PMID： 24853636      PMCID： PMC4227940          DOI： 10.1111/dom.12318

Source DB:  PubMed          Journal:  Diabetes Obes Metab        ISSN： 1462-8902            Impact factor:   6.577


  29 in total

1.  Intentional weight loss and mortality among overweight individuals with diabetes.

Authors:  D F Williamson; T J Thompson; M Thun; D Flanders; E Pamuk; T Byers
Journal:  Diabetes Care       Date:  2000-10       Impact factor: 19.112

2.  2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society.

Authors:  Michael D Jensen; Donna H Ryan; Caroline M Apovian; Jamy D Ard; Anthony G Comuzzie; Karen A Donato; Frank B Hu; Van S Hubbard; John M Jakicic; Robert F Kushner; Catherine M Loria; Barbara E Millen; Cathy A Nonas; F Xavier Pi-Sunyer; June Stevens; Victor J Stevens; Thomas A Wadden; Bruce M Wolfe; Susan Z Yanovski; Harmon S Jordan; Karima A Kendall; Linda J Lux; Roycelynn Mentor-Marcel; Laura C Morgan; Michael G Trisolini; Janusz Wnek; Jeffrey L Anderson; Jonathan L Halperin; Nancy M Albert; Biykem Bozkurt; Ralph G Brindis; Lesley H Curtis; David DeMets; Judith S Hochman; Richard J Kovacs; E Magnus Ohman; Susan J Pressler; Frank W Sellke; Win-Kuang Shen; Sidney C Smith; Gordon F Tomaselli
Journal:  Circulation       Date:  2013-11-12       Impact factor: 29.690

3.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

Authors:  William C Knowler; Elizabeth Barrett-Connor; Sarah E Fowler; Richard F Hamman; John M Lachin; Elizabeth A Walker; David M Nathan
Journal:  N Engl J Med       Date:  2002-02-07       Impact factor: 91.245

Review 4.  Weight loss and mortality in persons with type-2 diabetes mellitus: a review of the epidemiological evidence.

Authors:  D F Williamson
Journal:  Exp Clin Endocrinol Diabetes       Date:  1998       Impact factor: 2.949

Review 5.  Long-term effects of change in body weight on all-cause mortality. A review.

Authors:  R Andres; D C Muller; J D Sorkin
Journal:  Ann Intern Med       Date:  1993-10-01       Impact factor: 25.391

6.  Weight loss and subsequent death in a cohort of U.S. adults.

Authors:  E R Pamuk; D F Williamson; M K Serdula; J Madans; T E Byers
Journal:  Ann Intern Med       Date:  1993-10-01       Impact factor: 25.391

7.  Benefits and adverse effects of weight loss. Observations from the Framingham Study.

Authors:  M Higgins; R D'Agostino; W Kannel; J Cobb; J Pinsky
Journal:  Ann Intern Med       Date:  1993-10-01       Impact factor: 25.391

8.  Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes.

Authors:  Donna H Ryan; Mark A Espeland; Gary D Foster; Steven M Haffner; Van S Hubbard; Karen C Johnson; Steven E Kahn; William C Knowler; Susan Z Yanovski
Journal:  Control Clin Trials       Date:  2003-10

9.  Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial.

Authors:  Benjamin N Breyer; Suzanne Phelan; Patricia E Hogan; Raymond C Rosen; Abbas E Kitabchi; Rena R Wing; Jeanette S Brown
Journal:  J Urol       Date:  2014-02-14       Impact factor: 7.450

10.  Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes.

Authors:  Mark A Espeland; Henry A Glick; Alain Bertoni; Frederick L Brancati; George A Bray; Jeanne M Clark; Jeffrey M Curtis; Caitlin Egan; Mary Evans; John P Foreyt; Siran Ghazarian; Edward W Gregg; Helen P Hazuda; James O Hill; Don Hire; Edward S Horton; Van S Hubbard; John M Jakicic; Robert W Jeffery; Karen C Johnson; Steven E Kahn; Tina Killean; Abbas E Kitabchi; William C Knowler; Andrea Kriska; Cora E Lewis; Marsha Miller; Maria G Montez; Anne Murillo; David M Nathan; Ebenezer Nyenwe; Jennifer Patricio; Anne L Peters; Xavier Pi-Sunyer; Henry Pownall; J Bruce Redmon; Julia Rushing; Donna H Ryan; Monika Safford; Adam G Tsai; Thomas A Wadden; Rena R Wing; Susan Z Yanovski; Ping Zhang
Journal:  Diabetes Care       Date:  2014-09       Impact factor: 19.112
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  4 in total

1.  Family physician-led, team-based, lifestyle intervention in patients with metabolic syndrome: results of a multicentre feasibility project.

Authors:  Khursheed Jeejeebhoy; Rupinder Dhaliwal; Daren K Heyland; Roger Leung; Andrew G Day; Paula Brauer; Dawna Royall; Angelo Tremblay; David M Mutch; Lew Pliamm; Caroline Rhéaume; Doug Klein
Journal:  CMAJ Open       Date:  2017-03-14

Review 2.  Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations.

Authors:  Cecilia C Low Wang; Connie N Hess; William R Hiatt; Allison B Goldfine
Journal:  Circulation       Date:  2016-06-14       Impact factor: 29.690

3.  A novel multidisciplinary intervention for long-term weight loss and glycaemic control in obese patients with diabetes.

Authors:  Anna Lih; Lorraine Pereira; Ramy H Bishay; Johnson Zang; Abdullah Omari; Evan Atlantis; Nic Kormas
Journal:  J Diabetes Res       Date:  2015-04-08       Impact factor: 4.011

4.  Low Carbohydrate Diets and Type 2 Diabetes: What is the Latest Evidence?

Authors:  Pamela Dyson
Journal:  Diabetes Ther       Date:  2015-10-07       Impact factor: 2.945
  4 in total

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