BACKGROUND: Chronic pancreatitis (CP) is a rare disease in childhood. Although ERCP is commonly performed in children, the effect of pancreatic duct stenting therapy in children with CP is unknown. OBJECTIVE: To investigate the efficacy of pancreatic duct stenting in children with CP. DESIGN: Retrospective analysis. SETTING: National referral center. PATIENTS: A total of 208 children with CP hospitalized between 1988 and 2012. INTERVENTIONS: ERCP with pancreatic duct stenting. MAIN OUTCOME MEASUREMENTS: Results of endoscopic therapy and number of pancreatitis episodes per year before and after treatment. RESULTS: A total of 223 pancreatic duct stenting procedures were performed in 72 children. The median number of stent replacements was 3 (range 1-21). A statistically significant decrease in the number of pancreatitis episodes per year was observed: from 1.75 to 0.23 after endoscopic treatment (P < .05). Pancreatic duct stenting was performed more frequently in patients with hereditary pancreatitis (61.5%) and in children with CP and anatomic anomalies of the pancreatic duct (65%; P < .05). LIMITATIONS: Retrospective analysis with the assessment of adverse events based on medical history. CONCLUSION: Pancreatic duct stenting therapy is a safe and effective procedure in children with CP. This therapy should be recommended especially for children with hereditary pancreatitis and patients with anatomic anomalies of the pancreatic duct.
BACKGROUND:Chronic pancreatitis (CP) is a rare disease in childhood. Although ERCP is commonly performed in children, the effect of pancreatic duct stenting therapy in children with CP is unknown. OBJECTIVE: To investigate the efficacy of pancreatic duct stenting in children with CP. DESIGN: Retrospective analysis. SETTING: National referral center. PATIENTS: A total of 208 children with CP hospitalized between 1988 and 2012. INTERVENTIONS: ERCP with pancreatic duct stenting. MAIN OUTCOME MEASUREMENTS: Results of endoscopic therapy and number of pancreatitis episodes per year before and after treatment. RESULTS: A total of 223 pancreatic duct stenting procedures were performed in 72 children. The median number of stent replacements was 3 (range 1-21). A statistically significant decrease in the number of pancreatitis episodes per year was observed: from 1.75 to 0.23 after endoscopic treatment (P < .05). Pancreatic duct stenting was performed more frequently in patients with hereditary pancreatitis (61.5%) and in children with CP and anatomic anomalies of the pancreatic duct (65%; P < .05). LIMITATIONS: Retrospective analysis with the assessment of adverse events based on medical history. CONCLUSION:Pancreatic duct stenting therapy is a safe and effective procedure in children with CP. This therapy should be recommended especially for children with hereditary pancreatitis and patients with anatomic anomalies of the pancreatic duct.
Authors: Amit S Grover; Alvin J Freeman; Maisam Abu-El-Haija; John F Eisses; Timothy B Gardner; Quin Y Liu; Mark E Lowe; Jaimie D Nathan; Tonya M Palermo; Vikesh K Singh; Andrew T Trout; Aliye Uc; Sohail Z Husain; Veronique D Morinville Journal: J Pediatr Gastroenterol Nutr Date: 2019-02 Impact factor: 2.839
Authors: D Kohoutova; A Tringali; G Papparella; V Perri; I Boškoski; J Hamanaka; G Costamagna Journal: United European Gastroenterol J Date: 2018-12-05 Impact factor: 4.623
Authors: David M Troendle; Douglas S Fishman; Bradley A Barth; Matthew J Giefer; Tom K Lin; Quin Y Liu; Maisam Abu-El-Haija; Melena D Bellin; Peter R Durie; Steven D Freedman; Cheryl Gariepy; Tanja Gonska; Melvin B Heyman; Ryan Himes; Sohail Z Husain; Soma Kumar; Mark E Lowe; Veronique D Morinville; Chee Y Ooi; Joseph Palermo; John F Pohl; Sarah Jane Schwarzenberg; Steven Werlin; Michael Wilschanski; M Bridget Zimmerman; Aliye Uc Journal: Pancreas Date: 2017-07 Impact factor: 3.327
Authors: Margaret G Keane; Mayur Kumar; Natascha Cieplik; Douglas Thorburn; Gavin J Johnson; George J Webster; Michael H Chapman; Keith J Lindley; Stephen P Pereira Journal: BMC Pediatr Date: 2018-02-09 Impact factor: 2.125