Literature DB >> 24849662

Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation?

Johannes Boltze1, Barbara Lukomska2, Jukka Jolkkonen3.   

Abstract

Experimental stroke treatment by mesenchymal stem cell (MSC) populations is an attractive paradigm in stroke research. There are many studies describing improved functional outcomes after MSC delivery in stroke, but the mechanisms through which the transferred cells exert these effects are less well understood. Moreover, commonly applied functional tests may not be suitable for discriminating real functional recovery from compensation, which is a frequently encountered phenomenon in rodents. This commentary highlights some of the potential risks for the translational process associated with these tests and proposes some alternative test arrays which may achieve more specific functional phenotyping.

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Year:  2014        PMID： 24849662      PMCID： PMC4126100          DOI： 10.1038/jcbfm.2014.94

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  10 in total

Review 1.  Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic.

Authors:  Zheng Gang Zhang; Michael Chopp
Journal:  Lancet Neurol       Date:  2009-05       Impact factor: 44.182

Review 2.  What do motor "recovery" and "compensation" mean in patients following stroke?

Authors:  Mindy F Levin; Jeffrey A Kleim; Steven L Wolf
Journal:  Neurorehabil Neural Repair       Date:  2008-12-31       Impact factor: 3.919

3.  Enriched environment promotes efficiency of compensatory movements after cerebral ischemia in rats.

Authors:  M Knieling; G A Metz; I Antonow-Schlorke; O W Witte
Journal:  Neuroscience       Date:  2009-07-07       Impact factor: 3.590

4.  Cell-based therapies and functional outcome in experimental stroke.

Authors:  Anna Hicks; Timothy Schallert; Jukka Jolkkonen
Journal:  Cell Stem Cell       Date:  2009-08-07       Impact factor: 24.633

Review 5.  Experimental approaches to study functional recovery following cerebral ischemia.

Authors:  Anu Lipsanen; Jukka Jolkkonen
Journal:  Cell Mol Life Sci       Date:  2011-05-29       Impact factor: 9.261

Review 6.  Rat models of upper extremity impairment in stroke.

Authors:  Jeffrey A Kleim; Jeffery A Boychuk; DeAnna L Adkins
Journal:  ILAR J       Date:  2007

Review 7.  Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke.

Authors:  Mark A Eckert; Quynh Vu; Kate Xie; Jingxia Yu; Wenbin Liao; Steven C Cramer; Weian Zhao
Journal:  J Cereb Blood Flow Metab       Date:  2013-06-12       Impact factor: 6.200

8.  Improvement after constraint-induced movement therapy: recovery of normal motor control or task-specific compensation?

Authors:  Tomoko Kitago; Johnny Liang; Vincent S Huang; Sheila Hayes; Phyllis Simon; Laura Tenteromano; Ronald M Lazar; Randolph S Marshall; Pietro Mazzoni; Laura Lennihan; John W Krakauer
Journal:  Neurorehabil Neural Repair       Date:  2012-07-13       Impact factor: 3.919

9.  From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier?

Authors:  Linan Liu; Mark A Eckert; Hamidreza Riazifar; Dong-Ku Kang; Dritan Agalliu; Weian Zhao
Journal:  Stem Cells Int       Date:  2013-08-12       Impact factor: 5.443

10.  A concerted appeal for international cooperation in preclinical stroke research.

Authors:  Ulrich Dirnagl; Antoine Hakim; Malcolm Macleod; Marc Fisher; David Howells; Stuart M Alan; Gary Steinberg; Anna Planas; Johannes Boltze; Sean Savitz; Costantino Iadecola; Stephen Meairs
Journal:  Stroke       Date:  2013-04-18       Impact factor: 7.914
  10 in total
  29 in total

Review 1.  Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story.

Authors:  Gabrielle Mangin; Nathalie Kubis
Journal:  Stem Cell Rev Rep       Date:  2019-04       Impact factor: 5.739

Review 2.  Stem Cell Recipes of Bone Marrow and Fish: Just What the Stroke Doctors Ordered.

Authors:  Eleonora Napoli; Cesar V Borlongan
Journal:  Stem Cell Rev Rep       Date:  2017-04       Impact factor: 5.739

Review 3.  Optimizing functional outcome endpoints for stroke recovery studies.

Authors:  Mustafa Balkaya; Sunghee Cho
Journal:  J Cereb Blood Flow Metab       Date:  2019-09-14       Impact factor: 6.200

4.  Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

Authors:  Yejie Shi; Xiaoyan Jiang; Lili Zhang; Hongjian Pu; Xiaoming Hu; Wenting Zhang; Wei Cai; Yanqin Gao; Rehana K Leak; Richard F Keep; Michael V L Bennett; Jun Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-30       Impact factor: 11.205

5.  Academic-industry Collaborations in Translational Stroke Research.

Authors:  Johannes Boltze; Daniel-Christoph Wagner; Henryk Barthel; Matthew J Gounis
Journal:  Transl Stroke Res       Date:  2016-06-14       Impact factor: 6.829

6.  Regulated and Unregulated Clinical Trials of Stem Cell Therapies for Stroke.

Authors:  Michael G Liska; Marci G Crowley; Cesar V Borlongan
Journal:  Transl Stroke Res       Date:  2017-01-26       Impact factor: 6.829

7.  The future of stem cell therapy for stroke rehabilitation.

Authors:  Cesar V Borlongan; Jukka Jolkkonen; Olivier Detante
Journal:  Future Neurol       Date:  2015-08

Review 8.  Cell Therapy in Stroke-Cautious Steps Towards a Clinical Treatment.

Authors:  Olivier Detante; Keith Muir; Jukka Jolkkonen
Journal:  Transl Stroke Res       Date:  2017-11-17       Impact factor: 6.829

Review 9.  Translational Hurdles in Stroke Recovery Studies.

Authors:  Jukka Jolkkonen; Gert Kwakkel
Journal:  Transl Stroke Res       Date:  2016-03-22       Impact factor: 6.829

10.  Recent Advances in Stem Cell-Based Therapeutics for Stroke.

Authors:  Eleonora Napoli; Cesar V Borlongan
Journal:  Transl Stroke Res       Date:  2016-08-12       Impact factor: 6.829
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