Literature DB >> 27301976

Academic-industry Collaborations in Translational Stroke Research.

Johannes Boltze1,2, Daniel-Christoph Wagner3, Henryk Barthel4, Matthew J Gounis5.   

Abstract

Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or intercontinental research programs. This development has recently been paralleled by first successful attempts to overcome the translational stroke research road block, such as the unprecedented success of novel endovascular approaches or the advent of the multicenter preclinical trial concept. While the first underlines the role of the industry as a major innovation driver in stroke research, the latter will require enrollment of industrial partners for optimal output. Moreover, academic-industry partnerships are invaluable to bridge the translational "valley of death" as well as funding gaps in times of dwindling public funding and declining high risk capital investments. However, these collaborations are also subject to relevant challenges because interests, values, and aims often significantly differ between cademia and industry. Here, we describe common academic-industry collaboration models as well as associated benefits and challenges in the stroke research arena. We also suggest strategies for improved planning, implementation, guidance, and utilization of academic-industry collaborations to the maximum mutual benefit.

Entities:  

Keywords:  Academic-industry collaboration; Research alliances; Stroke research; Translational research

Mesh:

Year:  2016        PMID: 27301976     DOI: 10.1007/s12975-016-0475-5

Source DB:  PubMed          Journal:  Transl Stroke Res        ISSN: 1868-4483            Impact factor:   6.829


  43 in total

Review 1.  Bundled Payment and Care of Acute Stroke: What Does it Take to Make it Work?

Authors:  David Bruce Matchar; Hai V Nguyen; Yuan Tian
Journal:  Stroke       Date:  2015-04-09       Impact factor: 7.914

2.  At issue: A model for academic/industry collaboration.

Authors:  William T Carpenter; James I Koenig; Graeme Bilbe; Serge Bischoff
Journal:  Schizophr Bull       Date:  2004       Impact factor: 9.306

3.  Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow.

Authors:  Mark K Borsody; Chisa Yamada; Dawn Bielawski; Tamara Heaton; Bruce Lyeth; Andrea Garcia; Fernando Castro Prado; Joaquín Azpiroz; Emilio Sacristan
Journal:  Brain Res       Date:  2013-07-11       Impact factor: 3.252

4.  Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines.

Authors:  Johannes Boltze; Cenk Ayata; Daniel-Christoph Wagner; Nikolaus Plesnila
Journal:  Stroke       Date:  2014-01-09       Impact factor: 7.914

5.  The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent.

Authors:  Bruce C V Campbell; Archana Purushotham; Soren Christensen; Patricia M Desmond; Yoshinari Nagakane; Mark W Parsons; Maarten G Lansberg; Michael Mlynash; Matus Straka; Deidre A De Silva; Jean-Marc Olivot; Roland Bammer; Gregory W Albers; Geoffrey A Donnan; Stephen M Davis
Journal:  J Cereb Blood Flow Metab       Date:  2011-07-20       Impact factor: 6.200

6.  In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe.

Authors:  Ilknur Ay; Francesco Blasi; Tyson A Rietz; Nicholas J Rotile; Sreekanth Kura; Anna Liisa Brownell; Helen Day; Bruno L Oliveira; Richard J Looby; Peter Caravan
Journal:  Circ Cardiovasc Imaging       Date:  2014-04-28       Impact factor: 7.792

Review 7.  Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions.

Authors:  David J Gladstone; Sandra E Black; Antoine M Hakim
Journal:  Stroke       Date:  2002-08       Impact factor: 7.914

Review 8.  Neuroprotection in acute ischemic stroke--current status.

Authors:  E Auriel; N M Bornstein
Journal:  J Cell Mol Med       Date:  2010-09       Impact factor: 5.310

9.  A concerted appeal for international cooperation in preclinical stroke research.

Authors:  Ulrich Dirnagl; Antoine Hakim; Malcolm Macleod; Marc Fisher; David Howells; Stuart M Alan; Gary Steinberg; Anna Planas; Johannes Boltze; Sean Savitz; Costantino Iadecola; Stephen Meairs
Journal:  Stroke       Date:  2013-04-18       Impact factor: 7.914

Review 10.  Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke.

Authors:  Arun Paul Amar; John H Griffin; Berislav V Zlokovic
Journal:  Front Cell Neurosci       Date:  2015-09-02       Impact factor: 5.505

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  7 in total

1.  To Improve Translational Research in Subarachnoid Hemorrhage.

Authors:  Hidenori Suzuki; Fumi Nakano
Journal:  Transl Stroke Res       Date:  2017-06-16       Impact factor: 6.829

2.  Challenges and Controversies in Translational Stroke Research - an Introduction.

Authors:  Johannes Boltze; Cenk Ayata
Journal:  Transl Stroke Res       Date:  2016-08-31       Impact factor: 6.829

3.  Correcting the Trajectory of Stroke Therapeutic Research.

Authors:  Keith R Pennypacker; Gregory Bix; Justin F Fraser
Journal:  Transl Stroke Res       Date:  2016-12-30       Impact factor: 6.829

Review 4.  Cell Therapy in Stroke-Cautious Steps Towards a Clinical Treatment.

Authors:  Olivier Detante; Keith Muir; Jukka Jolkkonen
Journal:  Transl Stroke Res       Date:  2017-11-17       Impact factor: 6.829

Review 5.  Cerebral venous collaterals: A new fort for fighting ischemic stroke?

Authors:  Lu-Sha Tong; Zhen-Ni Guo; Yi-Bo Ou; Yan-Nan Yu; Xiao-Cheng Zhang; Jiping Tang; John H Zhang; Min Lou
Journal:  Prog Neurobiol       Date:  2017-12-02       Impact factor: 11.685

6.  BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain.

Authors:  Xinxin Han; Liming Yu; Qingqing Chen; Min Wang; Jie Ren; Guangming Wang; Yihong Chen; Lixia Lu; Haibin Tian; Li Chen; Ying Zhang; Yuehua Liu; Hua He; Zhengliang Gao
Journal:  Stem Cells Int       Date:  2017-09-20       Impact factor: 5.443

Review 7.  Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives.

Authors:  Diji Kuriakose; Zhicheng Xiao
Journal:  Int J Mol Sci       Date:  2020-10-15       Impact factor: 5.923

  7 in total

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